Category Archives: IN THE SPOTLIGHT

New Multiple Myeloma Drug Set to Begin Clinical Trials|Specialty Pharmacy TIme


Specialty Pharmacy News

Treatment inhibits key process that enables cancer cells to multiply.

Researchers in London plan to begin clinical trials on a significant new treatment for multiple myeloma by the end of next year.

In laboratory testing, the drug, known as DTP3, killed myeloma cells within human cells and mice without causing any toxic side effects. In a paper published on October 13, 2014 in Cancer Cells, researchers outlined how the drug inhibits a key process that allows cancer cells to multiply.

“Lab studies suggest that DTP3 could have therapeutic benefit for patients with multiple myeloma and potentially several other types of cancer, but we will need to confirm this in our clinical trials, the first of which will start next year,” said lead researcher Professor Guido Franzoso in a press release.

DTP3 was developed through an evaluation of the mechanisms that enable cancer cells to continue multiplying beyond their normal lifespan. Specifically, the researchers studied a protein called nuclear factor kappa B (NF-kB), which plays a key role in inflammation, in addition to immune and stress response systems.

“We had known for many years that NF-kB is very important for cancer cells, but because it is also needed by healthy cells, we did not know how to block it specifically,” Franzoso said. “The discovery that blocking the GADD45β/MKK7 segment of the NF-κB pathway with our DTP3 peptide therapeutic selectively kills myeloma cells could offer a completely new approach to treating patients with certain cancers, such as multiple myeloma.” – See more at: http://www.specialtypharmacytimes.com/news/New-Multiple-Myeloma-Drug-Set-to-Begin-Clinical-Trials#sthash.XGAUTmks.Gyz2Cy02.dpuf

via New Multiple Myeloma Drug Set to Begin Clinical Trials.

this pressed for your right to know: Photos: ‘Living On A Dollar A Day’ Features Stark Portraits of Humanity|NewsWeek


Filed Under: World

10_17_DollarDay_Cover

Living on a dollar a day seems nearly unfathomable, but roughly one in six people in our world do on a daily basis. For her work Living On A Dollar A Day, photographer Renée C. Byer teamed up with San Francisco nonprofit The Forgotten International and ventured to four continents to capture intimate stills of people affected by extreme poverty.

“For me it’s very important to go behind the scenes and into their home to find pieces of daily life that everyone can relate to,” Byers said in an interview with National Geographic. “So people aren’t seeing a photo that will push them away, but will pull them back into the scene. So they’re not being overwhelmed by the emotion, but they’re able to relate to the emotion. So that they can imagine themselves trying to live this life, and in some way, hopefully, they could help.”

via

Photos: ‘Living On A Dollar A Day’ Features Stark Portraits of Humanity | newsweek

Béla Bartók – Rhapsody No.1 for Violin and Orchestra: make music part of your life series


Béla Bartók – Rhapsody No.1 for Violin and Orchestra

Rossini: Overture to The Barber of Seville – La Jolla Music Society SummerFest: make music part of your life series


Rossini: Overture to The Barber of SevilleLa Jolla Music Society SummerFest

Sibelius, Symphonie Nr 7 C Dur op 105 Leonard Bernstein, Wiener Philharmoniker: great compositions/performances


Sibelius, Symphonie Nr 7 C Dur op 105 Leonard Bernstein, Wiener Philharmoniker

Brahms, J. – Tragic Overture, Op. 81 (Tragische Ouvertüre): great compositions/performances


Brahms, J. – Tragic Overture, Op. 81

Claude Debussy – Images pour orchestre: make music pat of yourf life series


Saint of the Day for Monday, October 20th, 2014: St. Paul of the Cross


Image of St. Paul of the Cross

St. Paul of the Cross

St. Paul of the Cross was born at Ovada in the Republic of Genoa, January 3, 1694. His infancy and youth were spent in great innocence and piety. He was inspired from on high to found a congregation; … continue reading

More Saints of the Day

today’s holiday: The Birth of the Bab


The Birth of the Bab

The Birth of the Bab is a holy day in the Baha’i religion to celebrate the birthday in 1819 of Mirza Ali Mohammad in Shiraz, Persia (now Iran). In 1844, Mirza Ali declared himself the Bab (meaning “gate”) and foretold the coming of one greater than he. The day, on which work is suspended, is a happy social occasion for Baha’is. More… Discuss

quotation: “Our deeds determine us, as much as we determine our deeds.” George Eliot


Our deeds determine us, as much as we determine our deeds.

George Eliot (1819-1880) Discuss

today’s birthday: Béla Lugosi (1882)


Béla Lugosi (1882)

Lugosi, a Hungarian-born US actor, is best known for his portrayal of Dracula in the Broadway stage production and subsequent film of Bram Stoker’s classic vampire story. He appeared in the 1931 film version wearing minimal makeup and using his natural, heavily accented voice. Following this memorable performance, Lugosi found himself frequently typecast as a horror film villain. When Lugosi died in 1956, his son and fourth wife decided to bury him wearing what part of his Dracula costume? More… Discuss

this day in the yesteryear: Peru and Chile Sign Treaty of Ancón (1883)


Peru and Chile Sign Treaty of Ancón (1883)

The Treaty of Ancón ended Peru’s involvement in the War of the Pacific, which broke out between Chile and the joint forces of Bolivia and Peru in 1879. Victorious, Chile annexed the Peruvian province of Tarapacá and gained substantial mineral-rich territories, leaving Bolivia without access to the sea. The loss of the coast remains an emotional issue for many Bolivians, who attribute their country’s problems to being landlocked. What items stolen during the war did Chile return to Peru in 2007? More… Discuss

Hopping Relatively Recent Development in Kangaroos


Hopping Relatively Recent Development in Kangaroos

Kangaroos are known for their characteristic hop, but they didn’t always get around like this. Analysis of the fossilized bones of extinct kangaroos called sthenurines finds that they were not anatomically cut out for hopping and likely got around instead by walking in much the same manner that humans do. Sthenurines lived in Australia from about 13 million years ago to about 30,000 years ago, going extinct around the same time that humans arrived on the continent, quite possibly as a result of human activities. More… Discuss

Roxelana


Roxelana

The story of Roxelana is a true rags-to-riches tale. Little is known of her early life, but she was likely born in Ukraine in the 16th century. At some point, she was captured by Crimean Tatars and taken as a slave. Brought to Constantinople (now Istanbul), she was selected to be a concubine in the harem of Sultan Suleiman the Magnificent. Roxelana soon gained Suleiman’s favor and—in a shocking break with tradition—he made her his legal wife. What did this mean for the sons she bore him? More… Discuss

Experts say Ebola virus unlikely to spread to North America | CTV Calgary News


Kathy Mueller, a former CTV news anchor, recently returned to Canada from Sierra Leone where she assisted the Red Cross dead body management team.

“While we were laying one person to rest, the grave next to them was being dug,” said Mueller. “It was a constant conveyor belt of burials.”

More than 1,200 people have contracted the Ebola virus in Liberia and the virus has claimed the lives of nearly 700 people.

via Experts say Ebola virus unlikely to spread to North America | CTV Calgary News.

this pressed for your right to know: What We Were Told About Ebola|FactCheck.org


At a July 28 press briefing concerning the Ebola outbreak in West Africa, Centers for Disease Control and Prevention official Stephan Monroe said the virus “poses little risk to the U.S. general population.” But, he added, “it’s possible that someone could become infected with the Ebola virus in Africa and then get on a plane to the U.S.” Monroe called this scenario a “very remote possibility,” but he didn’t say it could never happen, as the senator claimed.

via What We Were Told About Ebola |FactCheck.org

this pressed: 12 Incredible Photos That Prove Snails Live In A Magical World — Unmotivating


this pressed for your right to know: Schumer urges Obama to send Ebola experts to NYC..|TheTruth24.com


Sen. Charles Schumer wants the ​Obama administration to immediately put a team of experts on the ground in the Big Apple to ensure the safety of New Yorkers in case someone tests positive for Ebola.

Since the city that never sleeps has two ​international ​airports in the region — JFK and Newark — that see more people arriving from virus-​​ridden west African nations than any other ​part of the country, the ​D​emocratic lawmaker urged the ​​Centers for Disease Control and Prevention on Sunday to dispatch specialized teams to the city as a way to “remain vigilant” against the threat of Ebola.

“We’re also asking, while that team is on the ground here, that they go around and do the same thing our city and state health departments are doing, go inspect the hospitals to make sure that they have everything in place,” Schumer said Sunday.

via Schumer urges Obama to send Ebola experts to NYC...

this pressesd: Monomoy Refuge, MA testing latest in birding tracking electronics, called nano-tag— USFWS Refuge System


This pressed: ‘Addie Card, 12 years old, anemic little spinner in North Pownal Cotton Mill, Vermont, 1910′ by Lewis Hine


this pressed for your right to know: AP photographer captures Ebola outbreak in Africa in pictures


or view the video @  http://on.msnbc.com/1sZD1V7

Voice of America: Day in Photos — October 19, 2014


5 Palestinians take cover from rain inside a makeshift shelter near the ruins of their houses, which witnesses said were destroyed during a seven-week Israeli offensive, in the east of Gaza City. (Click here to access 12 more photos in a new window )

 

 

This pressed for your right to know: US aircraft drop arms and supplies to Kurdish fighters battling Islamic State in Syrian town of Kobane – US Central Command — BBC Breaking News


this pressed for your right to know: Oil is so much more than a fuel— Bloomberg News


IMPROMPTU IN MAGENTA


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IMPROMPTU IN MAGENTA

this pressed: BBC News – Iraq approves Australian anti-Islamic State forces


Islamic State has waged a brutal campaign to seize territory, displacing many thousands

Kurds are desperate for help, but Turkey is refusing to renege on its long-standing enmity

“We have reached an agreement for a legal framework and now it will be a matter for our military when our special forces will be deployed,” Ms Bishop said at the end of a two-day trip to Baghdad.

Despite a huge effort by the US and its allies, Islamic State militants are continuing to rule over large parts of Iraq and Syria.

In recent weeks, the group has carried out a wave of suicide attacks, and has fended off attacks by Iraq’s armed forces.

Militants are also embroiled in fighting with Kurdish forces in the northern Syrian town of Kobane.

BBC News – Iraq approves Australian anti-Islamic State forces.

this pressed for your right to know: I’m a Hazmat-Trained Hospital Worker: Here’s What No One Is Telling You About Ebola | Alternet


I’m a Hazmat-Trained Hospital Worker: Here’s What No One Is Telling You About Ebola | Alternet.

 

 “Ebola is brilliant.”

It is a superior virus that has evolved and fine-tuned its mechanism of transmission to be near-perfect. That’s why we’re all so terrified. We know we can’t destroy it. All we can do is try to divert it, outrun it. 

I’ve worked in health care for a few years now. One of the first

Cover of "The Hot Zone: A Terrifying True...

Cover of The Hot Zone: A Terrifying True Story

things I took advantage of was training to become FEMA-certified for hazmat ops in a hospital setting. My rationale for this was that, in my home state of Maine, natural disasters are almost a given. We’re also, though you may not know it, a state that has many major ports that receive hazardous liquids from ships and transport them inland. In the back of my mind, of course, I was aware that any hospital in the world could potentially find itself at

the epicenter of a scene from The Hot Zone. That was several years ago. Today I’m thinking, by God, I might actually have to use this training. Mostly, though, I’m aware of just that — that I did receive training. Lots of it.

this pressed for your right to know: Battle Over Ebola Travel Ban: Health Officials Call It a Big Mistake – NBC News.com


A Washington Post-ABC News Poll said that 67 percent of Americans support restricting entry to the U.S. to travelers who have been in Ebola-affected countries.

Other countries — most recently including Jamaica, Guyana, Trinidad and Tobago, Colombia, and St.Lucia — have already taken steps to ban travelers from Liberia, Guinea and Sierra Leone or restrict entry until after a 21-day quarantine. Nigeria, Senegal and Democratic Republic of Congo are also on some of the banned lists.

Battle Over Ebola Travel Ban: Health Officials Call It a Big Mistake – NBC News.com.

Beethoven’s 5th Piano E-flat major, Op. 73 (Emperor) – Daniel Barenboim (whole concert): great compositions/performances


 Beethoven’s 5th Piano E-flat major, Op. 73 (Emperor) – Daniel Barenboim (whole concert)

Dvorak The Wild Dove 1, Symphonic poem Op 110: make music part of your life series


Dvorak The Wild Dove 1, Symphonic poem Op 110

(“The Wilde Dove: Symphonic poem, B.198, Op.110″ by Royal Liverpool Philharmonic Orchestra/Libor Pesek (AmazonMP3))

euzicasa: Blue, White and Green: Turnbull Canyon-Audio (Nightfall In) The Far Dunes – Tim Fachen (moods) 2:23 George Bost


Blue, White and Green: Turnbull Canyon-Audio (Nightfall In) The Far Dunes – Tim Fachen (moods) 2:23

I created this video with the YouTube Video Editor (http://www.youtube.com/editor) Filmed with Android: LG OPTIMUS ELITE
White clouds, blue skies, all seen through the green branches of the trees, with a background of running breeze through the fresh, green leafage…If we are lucky enough we can just let it fill us with the miracle of nature we take for granted every moment because:
There is nothing to replace it, nothing to act as its surrogate, nothing in waiting, after all this natural creation is destroyed.
Respect and preserve nature, find its meaning keep it clean, as you would your garden…It is your garden!

This insignificant video was taken under a tree along the trail at Turnbull Canyon, yesterday. Enjoy!
This is my personal video: As such it cannot be used by any for profit organization, including any TV station in the USA, or Abroad (this selection does not appear anywhere in the long list…)

New at euzicasa—widget—mp3.li: your music library access here (Always opens in a new page)


mp3.li:  your music library access here

mp3.li: your music library access here (Always opens in a new page)

 

Saint of the Day for Sunday, October 19th, 2014: Sts. Isaac Jogues and Rene Goupil


quotation: Charles Dickens — “…it is a far, far better rest that I go to, than I have ever known.”)


It is a far, far better thing that I do, than I have ever done;

Charles Dickens (1812-1870) Discuss

today’s holiday: Bettara-Ichi Festival


Bettara-Ichi

 


The annual Pickle Market, or Sticky-Sticky Fair, is held near the Ebisu Shrine in Tokyo, Japan, to supply people with what they will need to observe the Ebisu Festival on the following day, October 20. People buy wooden images of Ebisu, good-luck tokens, and most importantly, the white, pickled radish known as bettara that is so closely identified with the fair. The Sticky-Sticky Fair was named after the way the pickled radishes were sold. Stall keepers used to dangle them from a rope so the buyer wouldn’t get his hands sticky from the malted rice in which the radishes had been pickled. More… Discuss

today’s birthday: Subrahmanyan Chandrasekhar (1910)


Subrahmanyan Chandrasekhar (1910)

For his contributions to the knowledge of the evolution of stars, Indian-American astrophysicist Subrahmanyan Chandrasekhar shared the 1983 Nobel Prize in Physics. His work advanced the understanding of white dwarfs, supernovas, neutron stars, and black holes. He determined the maximum mass of a stable white dwarf—about 1.44 solar masses, the Chandrasekhar limit—beyond which a star will ultimately collapse and become a neutron star or black hole. Who else in his family was a Nobel laureate? More… Discuss

this day in the yesteryear: US Government Prohibits All Exports to Cuba (1960)


US Government Prohibits All Exports to Cuba (1960)

After Cuba gained independence from Spain in 1898, US influence over the island grew. The two countries traded heavily until Fidel Castro rose to power in a bloody coup, and Cuba expropriated many American-owned land holdings. The US then enforced a prohibition of all exports to Cuba in 1960. Two years later, the US blockaded the island in order to compel the Soviet Union to dismantle its nuclear missile base. Although the word “embargo” exists in Spanish, what is the US embargo called in Cuba? More… Discuss

Part 2 of 2: The BBC is allowed to film in Cuba and show life under the absurd US trade embargo. Whilst the US moralises over a tiny Cuba, they do nothing about the likes of Iran, China and North Korea, who all have dubious human rights records. But of course, it’s easy to pick on a little island instead of a big country.
Recorded from BBC 1pm News, 26 February 2010.

Internet Addiction in Young Adults


Internet Addiction in Young Adults

The social self.

The social self. (Photo credit: Wikipedia)

The medical community remains divided on the existence of Internet addiction as a standalone psychological disorder, but support is growing. Studies suggest that Internet addiction is physiologically similar to other types of addiction, and a recent survey finds that 16 percent of young adults exhibit symptoms of Internet addiction, including spending inordinate amounts of time—more than 15 hours a day—online. Still, the American Psychiatric Association has yet to recognize Internet addiction as an independent condition in its Diagnostic and Statistical Manual of Mental Disorders (DSM). More… Discuss

Bryce Canyon: Watch this amayzing documentary clear your mind and enjoy


Bryce Canyon

Bryce Canyon National Park in 3D

Bryce Canyon National Park in 3D is a 37 minute documentary that covers the Park today in 3D stereography and some history about the Park. It completes the tour of the various vistas from the rim of the Paunsaugunt Plateau in south central Utah.
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Utah‘s Bryce Canyon is known for its spectacularly colorful landscape and its geological structures that resemble miniature cities, cathedrals, and spires. These structures, known as “hoodoos,” were formed when water, frost, and wind acted on alternate strata of soft and hard limestone, creating colorful and unique forms. The canyon region was settled by Mormon pioneers in the 1850s and was named for Ebenezer Bryce, who homesteaded in the area. How is Bryce said to have described the canyon? More… Discuss

 

 

A French boy introduces himself to Indian soldiers who had just arrived in France to fight, 1914|OnThisDay & Facts


Leonard Cohen – In My Secret Life lyrics plus: make music part of your life series (“…Looked through the paper. Makes you want to cry. Nobody cares if the people Live or die…”)


“In My Secret Life”

I saw you this morning.
You were moving so fast.
Can’t seem to loosen my grip
On the past.
And I miss you so much.
There’s no one in sight.
And we’re still making love
In My Secret Life.

I smile when I’m angry.
I cheat and I lie.
I do what I have to do
To get by.
But I know what is wrong,
And I know what is right.
And I’d die for the truth
In My Secret Life.

Hold on, hold on, my brother.
My sister, hold on tight.
I finally got my orders.
I’ll be marching through the morning,
Marching through the night,
Moving cross the borders
Of My Secret Life.

Looked through the paper.
Makes you want to cry.
Nobody cares if the people
Live or die.
And the dealer wants you thinking
That it’s either black or white.
Thank G-d it’s not that simple
In My Secret Life.

I bite my lip.
I buy what I’m told:
From the latest hit,
To the wisdom of old.
But I’m always alone.
And my heart is like ice.
And it’s crowded and cold
In My Secret Life.

Felix Mendelssohn-Piano Concerto No. 1 in G minor, Op. 25: great compositions/performances


Felix Mendelssohn: Piano Concerto No. 1 in G minor,  Op. 25:

  1. Molto allegro con fuoco in G minor
  2. Andante in E major
  3. Presto—Molto allegro e vivace in G major

this pressed for your right to know: Obama Says Ebola Travel Bans Could Make Things Worse – NBC News.com


WASHINGTON – President Barack Obama on Saturday urged Americans to avoid hysteria over Ebola, and played down the idea of travel bans from Ebola-ravaged countries in West Africa, explaining that restrictions could make things worse. Lawmakers this week urged Obama to bar people from Liberia, Sierra Leone and Guinea from entering the United States. Obama has said he is not philosophically opposed to travel bans, but in his weekly address made it clear that he is not leaning toward them.

“We can’t just cut ourselves off from West Africa,” Obama said, explaining it would make it harder to move health workers and supplies into the region, and would motivate people trying to get out the region to evade screening, making it harder to track cases. “Trying to seal off an entire region of the world – if that were even possible – could actually make the situation worse,” he said.

via Obama Says Ebola Travel Bans Could Make Things Worse – NBC News.com.

this pressed for your right to know: Where Do the World’s Wealthiest People Live? – Real Time Economics – WSJ


Of course, the U.S. has a lot of wealthy people because it’s a big country. But the analysis suggests that the U.S. is punching above its weight, even after accounting for population. Total wealth per adult increased by $340,340 in North America, or an increase of 10.2% from the prior year. Total wealth per adult grew by nearly $146,000 in Europe, an increase of 10.4%.

By contrast, wealth per adult grew just 2.3% in China and it fell 1.9% in Latin America and 3.1% in India.

via Where Do the World’s Wealthiest People Live? – Real Time Economics – WSJ.

this pressed for your right to know: 2nd Nurse with Ebola may have had worse case during flights..


via 2nd Nurse with Ebola may have had worse case during flights...

18/10/2014 07:20     by: CBSNews

this pressed for your right to know: Jack Layton’s hospital records were also accessed, Chow says – The Globe and Mail



Elizabeth Church and Kelly Grant
The Globe and Mail
Published Friday, Oct. 17 2014, 10:31 PM EDT
Last updated Friday, Oct. 17 2014, 11:29 PM EDT

Excerpts: One day after news that Toronto Mayor Rob Ford’s medical records were inappropriately accessed while he underwent cancer treatment, Olivia Chow has confirmed her late husband and former NDP leader Jack Layton had the same experience while in the care of another major Toronto hospital.

via   Jack Layton’s hospital records were also accessed, Chow says – The Globe and Mail.

today’s holiday: Boggy Bayou Mullet Festival


Boggy Bayou Mullet Festival

A festival of seafood, folk culture, sports, and pageants, the Boggy Bayou Mullet Festival has been held since 1976 in Niceville, Florida, to celebrate the unappreciated mullet, the underdog of seafood. The festival serves up 10 tons of fried and smoked mullet, plus it features beauty pageants, entertainment on stage all weekend, and arts and crafts on display. Beyond the mullet, food booths offer Cajun specialties like crawfish pie, gumbo, and gator sausage; American Indian staples of fried bread and pasole; barbecued rabbit; and stingray on a stick. More… Discuss

quotation: Lewis Carroll


I have had prayers answered – most strangely so sometimes – but I think our heavenly Father’s loving-kindness has been even more evident in what He has refused me.

Lewis Carroll (1832-1898) Discuss

today’s birthday: Chuck Berry (1926)


Chuck Berry (1926)

Berry was one of the most innovative musicians of the 1950s. His unique blues-derived guitar style and witty lyrics helped define the rock music genre and earned him one of the first spots in the Rock and Roll Hall of Fame. A dynamic performer, he is also known for his signature crouching and gliding “duck walk,” a move that has been imitated by many musicians. What legendary musician said, “If you tried to give rock and roll another name, you might call it ‘Chuck Berry'”? More… Discuss

this day in the yesteryear: Texas Instruments Announces First Commercial Transistor Radio (1954)


Texas Instruments Announces First Commercial Transistor Radio (1954)

Transistors are the basis of much modern electronic technology, including the most popular communications device in history: the transistor radio. Billions of these compact, portable radios were manufactured during the 1960s and 1970s. Battery-operated, they came in handy during electrical outages, and their pocket size sparked a change in popular music listening habits, allowing people to listen to music anywhere they went. When it was released in 1954, how much did the transistor radio cost? More… Discuss