Category Archives: News

The Hanging Gardens of Babylon


The Hanging Gardens of Babylon

The Hanging Gardens were one of the Seven Wonders of the Ancient World. According to legend, Babylonian King Nebuchadnezzar II built the gardens around 600 BCE to soothe his wife, who was homesick for her mountainous homeland. Though extensively documented by ancient historians, no extant Babylonian texts mention the gardens, and there is little physical evidence of their existence. Alternative theories suggest that the gardens were built by the Assyrian king Sennacherib near what modern city? More… Discuss

295 Thought Dead in New Malaysia Airlines Tragedy


295 Thought Dead in New Malaysia Airlines Tragedy

A Malaysia Airlines flight bound for Kuala Lumpur from Amsterdam crashed in eastern Ukraine yesterday, and it may not have been an accident. Ukraine has accused terrorists of shooting down the commercial flight, while the rebels have pointed the finger back at Ukraine. All 295 persons on board—280 passengers and 15 crew—are presumed dead. This is the second tragedy to strike the airline this year. In March, another flight went missing without a trace, and it has yet to be found. More… Discuss

NO WAY: Overpopulation


FROM WIKIPEDIA:  Overpopulation

Population growth that exceeds the carrying capacity of an area or environment results in overpopulation.[21] Spikes in human population can cause problems such as pollution, water crisis,[22][23] and poverty.[24][25] World population has grown from 1.6 billion in 1900 to an estimated 7 billion today. In Mexico alone, population has grown from 13.6 million in 1900 to 107 million in 2007.[26] Virginia Abernethy notes that immigration is a road that provides a “relief valve” to overpopulation that stops a population from addressing the consequences of its overpopulation and that exports this overpopulation to another location or country.[27]

In 2000, the United Nations estimated that the world’s population was growing at the rate of 1.14% (or about 75 million people) per year. According to data from the CIA’s World Factbook, the world human population currently increases by 145 every minute.[28] The United States Census Bureau issued a revised forecast for world population that increased its projection for the year 2050 to above 9.4 billion people, up from 9.1 billion people. There are a billion more added every 12 years. Almost all growth will take place in the less developed regions.[29]

make music part of your life series: Luigi Boccherini – Guitar Quintet in D major, G. 449 – IV. Andantino pausato con variazioni


Luigi Boccherini – Guitar Quintet in D major, G. 449 – IV. Andantino pausato con variazioni

Published on Jun 13, 2012

Zoltán Tokos, guitar. Danubius String Quartet. Judit Tóth, violin. Adél Miklós, violin. Eniko Nagy, viola. Ilona Ribli, cello.

Saint of the Day for Wednesday, July 16th, 2014: St. Carmen (Patronal Feast Day )


tghis day in the yesteryear: Shoemaker-Levy 9 Comet Collides with Jupiter (1994)


Shoemaker-Levy 9 Comet Collides with Jupiter (1994)

In March 1993, astronomers Carolyn and Eugene Shoemaker and David Levy made the first observation of a comet orbiting a planet rather than the Sun. Sixteen months later, fragments of the comet collided with Jupiter’s southern hemisphere, providing the first direct observation of the collision of two solar system objects. The impact left prominent scars that some said were more easily visible than the planet’s Great Red Spot. How did the event highlight Jupiter’s role as “cosmic vacuum cleaner“? More… Discuss

BBC News – In pictures: Rounding-up of wild horses in Galicia, Spain


 

BBC News – In pictures: Rounding-up of wild horses in Galicia, Spain.

Israeli commandos clash with Hamas gunmen in Gaza raid | Reuters


Israeli commandos clash with Hamas gunmen in Gaza raid | Reuters.

In Malaysia, Islam’s legal advance divides families and nation | Reuters


 

In Malaysia, Islam’s legal advance divides families and nation | Reuters.

Shocking!


Shocking!

The evolution of electric fish has long fascinated scientists, in part because the feature developed independently in six different groups of fish in disparate regions of the globe. Despite differences in the appearance and locations of these creatures’ electric organs, DNA evidence now shows that the genetic and biological pathways that brought about their electrification are the same in many if not all electric fish. More… Discuss

Espresso Machine’s Out-of-This-World Launch


Espresso Machine’s Out-of-This-World Launch

Coffee lovers of the world—nay, universe—rejoice! You will now be able to get a decent cup of joe in space. After decades of drinking subpar java, astronauts will finally have access to real Italian espresso in orbit. Engineers partnered with coffee giant Lavazza to design an espresso machine suitable for use on the International Space Station (ISS). The 44-pound (20-kg) “ISSpresso” machine is set to launch early next year on a cargo ship bound for the ISS, where Samantha Cristoforetti, Italy‘s first female astronaut, will also serve as the first space barista. More… Discuss

Video Calls Benefit Some Hospitalized Children


Video Calls Benefit Some Hospitalized Children

“Virtual visits” with loved ones help reduce stress for some—but not all—hospitalized children. Having access to video chat technology reduced stress levels for kids who lived an average of 35 miles from the hospital and were only hospitalized for about five days. However, pediatric patients whose hospital stays were longer or whose families lived farther away saw no real stress-reducing benefit from the technology. More… Discuss

this pressed: The NSA Revelations All in One Chart


ProPublica: The NSA Revelations All in One Chart
ProPublica: The NSA Revelations All in One Chart

via The NSA Revelations All in One Chart. (ProPublica)

health: “Drastic Action” Needed to Contain Ebola Outbreak in West Africa


“Drastic Action” Needed to Contain Ebola Outbreak in West Africa

The World Health Organization is calling for “drastic action” to contain the outbreak of Ebola currently raging in West Africa. Since the outbreak began four months ago, it has spread from Guinea to nearby Sierra Leone and Liberia, infected more than 600 people, and claimed nearly 400 lives, making it the largest Ebola outbreak in terms of cases, deaths, and geographical spread. Despite the presence of 150 experts, the number of reported cases and deaths is still rising daily, threatening the entire region and beyond. The charity Médecins Sans Frontières, or Doctors Without Borders, says the outbreak is out of control. More… Discuss

this pressed: Google I/O – What We Now Know – Forbes (google should use the profits in a socially responsible manner e.g. why not invest in nanothechnology to help the autoimune system fight, conquer and eradicate Multiple Myeloma ? instead of stupid robots?)


Google I/O: What We Now Know – Forbes.

make music part of your life series: Singer-songwriter Val Ghent at Cornelia Street Cafe Night of the Killer Keyboarders


Singer-songwriter Val Ghent @ Cornelia Street Cafe Night of the Killer Keyboarders

Day to Day Dream.http://www.valghent.com/ “Present Day Funk Sister” Valerie Ghent With Her Brothers Clayton Bryant, Tinker Barfield & Robin Macatangay. valghent.com

UNRELIABLE applications: if all other appications would be as bad we would not have an INTERNET: I’d saqy why fix it create new applications, accept them, and demonololize! this is ridiculously sad!


Adobe Flash & Shockwave - Mizarable applications - Why are we stuck with them

Adobe Flash & Shockwave – Unreliable applications – Why are we stuck with them

Adobe Shockwave Player Logo

Adobe Shockwave Player Logo (Photo credit: Wikipedia)

“A Plug-in (Shockwave Flash) isn’t responding” “Stop Plug-in.”

17 posts by 13 authors

All you hear for years is troubleshoot, is the browser, is the this and that.:  no it’s these two applications! 

Gnome-mime-application-x-shockwave-flash

Gnome-mime-application-x-shockwave-flash (Photo credit: Wikipedia)

Grapefruit–drug interactions From wikipedia (and other sources)


Grapefruit–drug interactions

From Wikipedia, the free encyclopedia
 

Grapefruit and grapefruit juice have been found to interact with numerous drugs (at least 85 by the latest[when?] count), in many cases resulting in adverse effects.[1] Organic compounds that are furanocoumarin derivatives interfere with the hepatic and intestinal enzyme cytochrome P450 isoform CYP3A4 and are believed to be primarily responsible for the effects of grapefruit on the enzyme. Bioactive compounds in grapefruit juice may also interfere with P-glycoprotein and organic anion transporting polypeptides (OATPs), either increasing or decreasing the bioavailability of a number of drugs. Pomelo (the Asian fruit which was crossed with an orange to produce grapefruit) also contains high amounts of furanocoumarin derivatives. Some grapefruit-pomelo hybrids have practically no furanocoumarin content, and one is a commercially viable seedless type.[2]

Affected drugs

The following drugs are affected by CYP3A4 inhibition with grapefruit compounds:

 

Amphetamines

List of Amphetamines That Interact With The Cytochrome P450 CYP2D6 enzyme:

Research has been done on the interaction between amphetamines and The Cytochrome P450 CYP2D6 enzyme, and researchers concluded that some parts of substrate molecules contribute to the binding of the enzyme. [11]

 

Additional drugs found to be affected by grapefruit juice include, but are not limited to:

Mechanism of the interaction

The CYP3A4 isoform of cytochrome P450 is located in both the liver and the enterocytes. Many oral drugs undergo first-pass (presystemic) metabolism by the enzyme. Several organic compounds found in grapefruit and specifically in grapefruit juice exert inhibitory action on drug metabolism by the enzyme. It has been established that a group of compounds called furanocoumarins are responsible for this interaction, and not flavonoids as was previously reported.[32] The list of active furanocoumarins found in grapefruit juice includes: bergamottin, bergapten, bergaptol and 6′,7′-dihydroxybergamottin.

This interaction is particularly dangerous when the drug in question has a low therapeutic index, so that a small increase in blood concentration can be the difference between therapeutic effect and toxicity. Grapefruit juice inhibits the enzyme only within the intestines, not in the liver or elsewhere in the body, and does not impact injected drugs. The degree of the effect varies widely between individuals and between samples of juice, and therefore cannot be accounted for a priori.

Another mechanism of interaction is possibly through the P-glycoprotein (Pgp) that is localized in the apical brush border of the enterocytes. Pgp transports lipophilic molecules out of the enterocyte back into the intestinal lumen. Drugs that possess lipophilic properties are either metabolised by CYP3A4 or removed into the intestine by the Pgp transporter. Both the Pgp and CYP3A4 may act synergistically as a barrier to many orally administered drugs. Therefore, their inhibition (both or alone) can markedly increase the bioavailability of a drug.

The interaction caused by grapefruit compounds lasts for up to 72 hours, and its effect is the greatest when the juice is ingested with the drug or up to 4 hours before the drug. [33][34][35]

Drugs affected by grapefruit juice[36]
Drug class Major Interactions Minor interactions
Antiarrhythmic agents amiodarone (Cordarone)
dronedarone (Multaq)
 
Antihistamines terfenadine (Seldane) (off the market)
diphenhydramine (Benadryl) (partially)
astemizole (Hismanal) (off the market)
 
Calcium channel antagonists   felodipine (Plendil)
nicardipine (Cardene)
nifedipine (Procardia)
nimodipine (Nimotop)
nisoldipine (Sular)
isradipine (DynaCirc)
Cholesterol-lowering drugs aka
Statins (HMG-CoA reductase inhibitors)
simvastatin (Zocor)
lovastatin (Mevacor)
atorvastatin (Lipitor)
cerivastatin (Baycol) (off the market)
Cough Suppressant/NMDA Antagonist dextromethorphan  
Erectile dysfunction drugs   sildenafil (Viagra)
tadalafil (Cialis)
vardenafil (Levitra)
HIV protease inhibitors   saquinavir (Invirase)
ritonavir (Norvir)
nelfinavir (Viracept)
amprenavir (Agenerase)
Hormones   ethinyl estradiol (Ortho-Cept, many others)
methylprednisolone (Medrol)
Immunosuppressants   cyclosporine (Sandimmune, Neoral)
tacrolimus (Prograf)
sirolimus (Rapamune)
mercaptopurine
Sedatives, hypnotics, and anxiolytics buspirone (Buspar) triazolam (Halcion)
midazolam (Versed)
diazepam (Valium)
zaleplon (Sonata)
alprazolam (Xanax)
Other psychotropics   carbamazepine (Tegretol)
trazodone (Desyrel)
quetiapine (Seroquel)
fluvoxamine (Luvox)
nefazodone (Serzone) (off the market)
Other miscellaneous drugs cisapride (Prepulsid, Propulsid)[37]  

References

  1. Bailey, David G.; Dresser, George; Arnold, J. Malcolm O. (2012). “Grapefruit-medication interactions: Forbidden fruit or avoidable consequences?”. Canadian Medical Association Journal (Canadian Medical Association). doi:10.1503/cmaj.120951. edit
  2. “– Hybrid grapefruit safe for prescription meds”. Futurity.org. Retrieved 2013-01-28.
  3. Template:Cite pubmed.gov
  4. Sugimoto K, Araki N, Ohmori M, et al. (2006). “Interaction between grapefruit juice and hypnotic drugs: comparison of triazolam and quazepam”. Eur. J. Clin. Pharmacol. 62 (3): 209–15. doi:10.1007/s00228-005-0071-1. PMID 16416305.
  5. “Ritonavir (Norvir)”. HIV InSite. UCSF. 2006-10-18. Retrieved 2008-03-12.
  6. Lee AJ, Chan WK, Harralson AF, Buffum J, Bui BC. (1999). “The effects of grapefruit juice on sertraline metabolism: an in vitro and in vivo study.”. Clin Ther. 21 (11): 1890–9. doi:10.1016/S0149-2918(00)86737-5. PMID 10890261.
  7. “Interactions of amphetamine analogs with human liver CYP2D6″. National Center for Biotechnology Information, U.S. National Library of Medicine.
  8. “SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions.”. Structural Bioinformatics Group, Institute of Physiology, Charité-University Medicine Berlin.
  9. “Methamphetamine-mediated oxidative stress induces astrocyte apoptosis via cytochrome P450 2E1″. National Center for Biotechnology Information, U.S. National Library of Medicine.
  10. “potent inhibition of P450 gene CYP2D6 on d-amphetamine, methylphenidate, and cocaine”. Department of Pharmacology, University of Toronto, Ontario, Canada.
  11. “Metabolism/ Metabolites of amphetamines interacting with The Cytochrome P450 CYP2D6 enzyme”. U.S. National Library of Medicine.
  12. Bailey DG, Dresser GK (2004). “Interactions between grapefruit juice and cardiovascular drugs”. Am J Cardiovasc Drugs 4 (5): 281–97. doi:10.2165/00129784-200404050-00002. PMID 15449971.
  13. Lilja JJ, Kivistö KT, Neuvonen PJ (August 1999). “Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin”. Clin. Pharmacol. Ther. 66 (2): 118–27. doi:10.1053/cp.1999.v66.100453001. PMID 10460065.
  14. Lilja JJ, Kivistö KT, Backman JT, Lamberg TS, Neuvonen PJ (1998). “Grapefruit juice substantially increases plasma concentrations of buspirone*”. Clinical Pharmacology & Therapeutics 64 (6): 655–660. doi:10.1016/S0009-9236(98)90056-X. PMID 9871430. edit
  15. Lilja, JJ; Laitinen, K; Neuvonen, PJ (September 2005). “Effects of grapefruit juice on the absorption of levothyroxine.”. British Journal of Clinical Pharmacology 60 (3): 337–41. doi:10.1111/j.1365-2125.2005.02433.x. PMC 1884777. PMID 16120075.
  16. Jetter A, Kinzig-Schippers M, Walchner-Bonjean M, et al. (2002). “Effects of grapefruit juice on the pharmacokinetics of sildenafil”. Clin. Pharmacol. Ther. 71 (1): 21–9. doi:10.1067/mcp.2002.121236. PMID 11823754.
  17. H. Hori, R. Yoshimura, N. Ueda, S. Eto, K. Shinkai, S. Sakata, O. Ohmori, T. Terao and J. Nakamura (2004). “Fluvoxamine, In Vivo Study” (PDF). J Clin Psychopharmacol 23 (4): 422–424. doi:10.1097/01.jcp.0000085423.74359.f2. PMID 12920426.
  18. Gasche Y, Daali Y, Fathi M, et al. (December 2004). “Codeine intoxication associated with ultrarapid CYP2D6 metabolism”. N. Engl. J. Med. 351 (27): 2827–31. doi:10.1056/NEJMoa041888. PMID 15625333. Retrieved 2008-05-11.
  19. Further characterization of a furanocoumarin-free grapefruit juice on drug disposition: studies with cyclosporine“, American Journal of Clinical Nutrition, Vol. 87, No. 4, 863-871, April 2008.
  20. [1] “Somelabel”
  21. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014525/ Mouly and Paine, Br J Clin Pharmacol. 2001 August; 52(2): 216–217.
  22. “Grapefruit and medication: A cautionary note”. Health.harvard.edu. Retrieved 2013-01-28.
  23. Wikipedia article on oxycodone metabolism; pharmaceutical insert w/ Purdue OxyContin tablets – http://en.wikipedia.org/wiki/Oxycodone#Metabolism
  24. “Grapefruit Interactions”. healthCentral. Retrieved 2013-01-28.
  25. Messaoud Benmebarek MD, Et al., M; Devaud, C; Gex-Fabry, M; Powell Golay, K; Brogli, C; Baumann, P; Gravier, B; Eap, CB (17 March 2004). “Effects of grapefruit juice on the pharmacokinetics of the enantiomers of methadone”. Clinical Pharmacology & Therapeutics 76 (1): 55–63. doi:10.1016/j.clpt.2004.03.007. PMID 15229464. Retrieved 2009-03-13.
  26. Elkader, A; Sproule, B (July 2005). “Bluprenorphine – Clinical pharmacokinetics in the treatment of opioid dependence”. Clinical Pharamacokinetics 44 (7): 661–680. doi:10.2165/00003088-200544070-00001. PMID 15966752. Retrieved 2013-02-24.
  27. [2][dead link]
  28. “HIGHLIGHTS OF PRESCRIBING INFORMATION”. Gene. Retrieved 2013-01-28.
  29. Dasgupta, Amitava; Meredith A. Reyes; Semyon A. Risin; Jeffrey K. Actor (3 December 2008). “Interaction of white and pink grapefruit juice with acetaminophen (paracetamol) in vivo in mice”. Journal of Medicinal Food 11 (4): 795–8. doi:10.1089/jmf.2008.0059. ISSN 1557-7600. PMID 19053875.
  30. Dresser, GK; Kim RB; Bailey DG (March 2005). “Effect of grapefruit juice volume on the reduction of fexofenadine bioavailability: possible role of organic anion transporting polypeptides.”. Clinical Pharmacological Therapeutics 77 (3): 170–7. PMID 15735611.
  31. Jellin J.M., et al. Pharmacist’s Letter/Prescriber’s Letter of Natural Medicines Comprehensive Database. 7th ed. Stockton, CA: Therapeutic Research Faculty. 2005. 626-629
  32. Paine MF, Widmer WW, Hart HL, et al. (May 2006). “A furanocoumarin-free grapefruit juice establishes furanocoumarins as the mediators of the grapefruit juice-felodipine interaction”. The American journal of clinical nutrition 83 (5): 1097–105. PMID 16685052.
  33. Lundahl J, Regardh CG, Edgar B, Johnsson G. Relationship between time of intake of grapefruit juice and its effect on pharmacokinetics and pharmacodynamics of felodipine in healthy subjects. Eur J Clin Pharmacol 1995;49:61-7.
  34. http://pharmacistanswers.com/grapefruit-juice-drug-interactions.html
  35. Greenblatt DJ, von Moltke LL, Harmatz JS, et al. Time course of recovery of cytochrome P450 3A function after single doses of grapefruit juice. Clin Pharmacol Ther 2003;75:121-9.
  36. Bakalar, Nicholas (2006-03-21). “Experts Reveal the Secret Powers of Grapefruit Juice”. The New York Times. p. F6. Retrieved 2008-05-21.
  37. Gross AS, Goh YD, Addison RS, Shenfield GM (April 1999). “Influence of grapefruit juice on cisapride pharmacokinetics”. Clin. Pharmacol. Ther. 65 (4): 395–401. doi:10.1016/S0009-9236(99)70133-5. PMID 10223776.

External links

 

UC Davis MIND Institute Study Finds Association Between Maternal Exposure to Agricultural Pesticides, Autism in Offspring



UC Davis MIND Institute Study Finds Association Between Maternal Exposure to Agricultural Pesticides, Autism in Offspring
.

mindinstitute.ucdavis.edu

Source: http://www.ucdmc.ucdavis.edu
The work was supported by grants from the National Institute of Environmental Health Sciences R01-ES015359, P01-ES011269 and U.S. Environmental Protection Agency Science to Achieve Results (STAR) grants R833292 and 829338. The study is available free of charge at:  http://ehp.niehs.nih.gov/1307044/

Mojave Desert


Mojave Desert

The Mojave Desert occupies a significant portion of southeastern California and parts of Utah, Nevada, and Arizona. It is named for the Mojave tribe of Native Americans, who made it their home. It is also home to the world’s largest Joshua tree forest and the third-tallest dunes in North America, the 600-foot-high Kelso Dunes. The desert’s Death Valley, the lowest, hottest, driest area of North America, has recorded some of the world’s highest air temperatures. What is the Mojave’s largest city? More… Discuss

WORLDTRUTHTV: REDEFINING 1% (DOES REBLOGGING REALLY CHANGE ANYTHING?)


WORLDTRUTHTV-REDEFING 1%

WORLDTRUTHTV-REDEFING 1%

Violent and Legal: The Shocking Ways School Kids are Being Pinned Down, Isolated Against Their Will – ProPublica


Violent and Legal: The Shocking Ways School Kids are Being Pinned Down, Isolated Against Their Will – ProPublica.

6 Awesome Alternatives to YouTube – The Next Web


 

6 Awesome Alternatives to YouTube – The Next Web.

Study finds link between pesticides and autism – Yahoo News


A California study finds that pregnant women who live near farms where pesticides are applied have a two-thirds higher risk of having children with autism (AFP Photo/Philippe Huguen)

A California study finds that pregnant women who live near farms where pesticides are applied have a two-thirds higher risk of having children with autism (AFP Photo/Philippe Huguen)

Study finds link between pesticides and autism – Yahoo News.

Refugee Numbers Highest Since World War II (51, 000, 000 people forced to leave their homes: shame on the world leaders and ONU!)


Refugee Numbers Highest Since
World War II

The number of refugees worldwide has risen to levels not seen since World War II. There are an estimated 51.2 million people now displaced from their homes by conflict and persecution. Of these, 6.3 million have been living in “protracted” refugee situations, meaning they have been refugees for years, even decades. The surge in refugees is straining available resources and destabilizing some of the countries to which they have fled. More… Discuss

Bad Pass Lands Man in Jail


Bad Pass Lands Man in Jail

Let this story be a lesson to any would-be contraband smugglers—do not try to toss a football filled with heroin, marijuana, tobacco, cell phones, and chargers over a prison fence unless you are certain you have the arm for it. A young man in Michigan is now behind bars and facing contraband charges after allegedly attempting this feat and failing, his football landing short between two fences at a state prison rather than in the inmates’ exercise yard. Not only did the boneheaded criminal fail to make his delivery, but he also attempted it in full view of one of the prison’s guards and was quickly apprehended. More… Discuss

Possible Mass Anthrax Exposure at CDC Labs (loosing the grip on reality?)


Possible Mass Anthrax Exposure at CDC Labs

As many as 75 scientists working in US federal government laboratories in Atlanta, Georgia, may have been accidentally exposed to live anthrax bacteria after staff members at a high-level facility failed to follow proper procedures to inactivate the deadly bacteria before sending the samples to lower-level labs for experimentation. The US Centers for Disease Control and Prevention, under whose watch the breach occurred, is now investigating the incident and is offering antibiotic treatment and vaccines to those who might have been exposed. More… Discuss

article: The Baths of Bath


The Baths of Bath

Bath is a city in southwest England famous for its baths, which are fed by the only natural hot springs in the country and which some believe have curative properties. The Romans established the city as Aquae Sulis in the first century, building elaborate, lead-lined baths with heating and cooling systems. These were rediscovered in 1755, by which time Bath, as it had since become known, had revived as a spa and become a resort city for the wealthy. What was Jane Austen‘s connection to Bath? More… Discuss

today’s holiday: Carberry Day


Carberry Day

The students and faculty at Brown University in Providence, Rhode Island, celebrate the fictitious academic exploits of Professor Josiah Stinkney Carberry every Friday the 13th. On Carberry Day, small brown jugs appear around campus, and students and teachers fill them with change. The money goes to a book fund that Professor Carberry has set up “in memory of my future late wife, Laura.” More… Discuss

Insurgents Take Second Iraqi City


Insurgents Take Second Iraqi City

Insurgents from the Islamic State of Iraq and the Levant (ISIS), an offshoot of al-Qaeda several thousand fighters strong that controls considerable territory in eastern Syria and western and central Iraq, have attacked cities around western and northern Iraq this week and taken two of them, Mosul and Tikrit. As many as 500,000 people fled Mosul after the city was attacked. Even security forces reportedly fled. But government leaders have vowed to repel the militants. More… Discuss

make music part of your life series: Rossini – Overture to The Barber of Seville – La Jolla Music Society SummerFest


Rossini: Overture to The Barber of SevilleLa Jolla Music Society SummerFest

(Visit: http://www.uctv.tv/)

Rossini’s Overture to “The Barber of Seville” is one of the most loved and best recognized works in the classical/opera repertoire, thanks in part to its use in countless movies, commercials, and of course, a Bugs Bunny cartoon (“Let me cut your top/Let me shave your mop…”. Renowned conductor Kent Nagano leads a stellar assemblage of chamber musicians in a spirited rendition of Rossini’s masterwork. Series: “La Jolla Music Society: SummerFest” [Arts and Music] [Show ID: 24597]

this pressed: Staatskapelle Dresden | Willkommen


Staatskapelle Dresden | Willkommen.

Richard Strauss – Metamorphosen, für 23 Streicher, Staatskapelle Dresden, Rudolf Kempe (1973): In Memoriam!


Richard Strauss – Metamorphosen, für 23 Streicher, Staatskapelle Dresden, Rudolf Kempe (1973)

Dresden WWII bombing pre- and after pictures (English) 

View of the city, aka Florence of the north.
After the bombing.
View of the city, aka Florence of the north. After the bombing.
Sophie-Church, as it looked before.
It's never been rebuild.
Sophie-Church, as it looked before. It’s never been rebuild.
Church of our Lady.
Collapsed later due to heavy destruction.
Church of our Lady. Collapsed later due to heavy destruction.
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today’s holiday: Kamehameha Celebration


Kamehameha Celebration

A state holiday in Hawaii to celebrate the island state’s first king, King Kamehameha I (1758?-1819), this celebration is the only public holiday in the United States that honors royalty. Leis are draped on the king’s statue across from Iolani Palace, and there is another lei-draping at Kapaau, North Kohala. A floral parade travels from downtown Honolulu to Waikiki, featuring a young man who depicts the king wearing a replica of the king’s golden amo-feather cloak and Grecian-style helmet. Other events include arts and crafts, a competition of chants and hulas, and a luau, or Hawaiian cookout. More… Discuss

Blood Transfusion


Blood Transfusion

A blood transfusion is the administration of whole blood or a component to counteract blood loss caused by trauma, surgery, or disease. In some cases, whole blood is not needed or is unavailable, so an individual component—plasma, red or white cells, platelets—is used. In whole-blood transfusions, the donor’s blood must be compatible with that of the recipient. Autologous transfusions are those that use the recipient’s own blood, banked in advance. When was the first human blood transfusion? More… Discuss

Love Poses Hazard on Paris Bridge


Français : Pont des Arts

Français : Pont des Arts (Photo credit: Wikipedia)

Love Poses Hazard on Paris Bridge

Paris is widely regarded as the romance capital of the world, and perhaps nowhere is this more apparent than its Pont des Arts footbridge spanning the Seine. The bridge has, in recent years, become a pilgrimage site for couples from all over the world, who have taken to leaving padlocks inscribed with their initials on the bridge’s fencing and tossing away the keys into the waters below to symbolize their enduring love for one another. Romantic as the gesture is, it has also proved to be quite destructive. Recently, a metal grill laden with “love locks” collapsed onto the bridge’s walkway. No one was hurt, but the incident highlights the danger of this seemingly innocuous practice. More… Discuss

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Obesity Weighs Heavily on World


Obesity Weighs Heavily on World

The burden of obesity has grown considerably in recent decades, with about 30 percent of the global population—a whopping 2.1 billion people—now overweight or obese. Over the past 33 years, obesity rates soared 28 percent in adults and 47 percent in children, and the number of overweight and obese people more than doubled. For now, the US retains the unenviable distinction of hosting the largest portion of the world’s obese—13 percent. Though obesity was once limited to rich nations, more than two-thirds of the world’s obese now live in developing countries. In the Middle East and North Africa, more than half of adult men and nearly two-thirds of adult women are overweight or obese. More… Discuss

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great compositions/performances: Johann Sebastian Bach – Fantasy and fugue in G minor BWV 542


Johann Sebastian Bach – Fantasy and fugue in G minor BWV 542

Franz Hauk at the Great Klais Organ of Liebfrauenmünster Ingolstadt

*****From Wikipedia, the free encyclopedia*****
The Great Fantasia and Fugue in G minor, BWV 542, is an organ prelude and fugue by Johann Sebastian Bach. It acquired that name to distinguish it from the earlier Little Fugue in G minor, which is shorter. This piece is not to be confused with the Prelude and Fugue in A minor, which is also for organ and also sometimes called “the Great”.

It was transcribed for piano by Franz Liszt as S.463.

Robert Huw Morgan plays Bach’s Fantasia and Fugue in G minor on the Fisk-Nanney organ at the Stanford Memorial Church in Stanford, California.

 

 

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Burt Lancaster – The Legacy (a few of the many motion features Burt Lancaster was featured in)


Burt Lancaster – The Legacy

Clips from:  The Leopard, The Rainmaker, Sweet Smell of Success, From Here to Eternity, Gunfight at the O.K. Corral, The Professionals, Atlantic City, Seven Days in May, The Killers, Birdman of Alcatraz, 1900, Judgment at Nuremberg, Separate Tables, The Swimmer and Elmer Gantry.

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this pressed: What is the Difference Between http and https? (with pictures): Encription, that’s what!


via What is the Difference Between http and https? (with pictures).

 

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Sleep Promotes Learning through Synapse Formation (there are so many studies arriving to other conclusions: Why?)


Sleep Promotes Learning through Synapse Formation

Sleep has long been known to play a vital role in the learning process, but the precise science behind it was not fully understood. Using advanced microscopy, researchers were able to observe the formation of new synapses, or connections between nerve cells, in the brain and found that sleep-deprived subjects form fewer new connections than those allowed to sleep properly. Even intense, extended training on a task cannot make up for sleep deprivation. The findings suggest that sleep promotes the formation of new synaptic connections, thereby contributing to learning and memory formation. More… Discuss

Just a thought: “What”s known for thousands of years, is as true now than it was in the early history of mankind…who pays for all the sensational studies done to prove the mumankind commun sense wrong? and why?” (George B)

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This Pressed: Internet Giants Erect Barriers to Spy Agencies – NYTimes.com


Excerpts from the article: A year after Mr. Snowden’s revelations, the era of quiet cooperation is over. Telecommunications companies say they are denying requests to volunteer data not covered by existing law. A.T.&T., Verizon and others say that compared with a year ago, they are far more reluctant to cooperate with the United States government in “gray areas” where there is no explicit requirement for a legal warrant.”

Google
Google (Photo credit: Carlos Luna)

InternetGiants Erect Barriers to Spy Agencies – NYTimes.com.

Google servers in Douglas County, Ga. The company is encrypting more data as it moves between servers. Credit Connie Zhou/Google
Robert Litt, of the Office of the Director of National Intelligence, bemoaned the new lack of the cooperation. Credit Yuri Gripas/Reuters
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this pressed: Israeli, Palestinian presidents in unprecedented Vatican prayers | Reuters


Israeli, Palestinian presidents in unprecedented Vatican prayers | Reuters.

Faithful wave Palestinian flags as Pope Francis delivers his Regina Coeli prayer from the window of the Apostolic Palace in Saint Peter's Square at the Vatican June 8, 2014. REUTERS/Giampiero Sposito

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Big Ben history and chimes!


Big Ben

Big Ben is the nickname of the clock tower at the Palace of Westminster in London. Famous for its accuracy, the clock rings in the new year in England.

Originally, only the Great Bell—the largest bell in the tower—was called “Big Ben,” but eventually, the moniker was applied to the clock itself and then to the entire tower. In 2012, the iconic British landmark was officially renamed Elizabeth Tower, in honor of Queen Elizabeth’s Diamond Jubilee. Who is generally accepted as the real-life “Ben”? More… Discuss

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5 Things to Know About Vodafone’s Surveillance Report – WSJ


Embedded image permalink

5 Things to Know About Vodafone’s Surveillance Report – WSJ.

great compositions/performances: Barbirolli – Arensky: Variations on a Theme by Tchaikovsky (improved sound)


Barbirolli – Arensky: Variations on a Theme by Tchaikovsky

London Symphony Orchestra
Recorded in 1947

John Barbirolli in the mid-1960s

John Barbirolli in the mid-1960s (Photo credit: Wikipedia)

John Barbirolli
Born: 12/2/1899 – Holborn, London, England
Died: 7/29/1970 – London, England

Anton Stepanovich Arensky (Russian: Антон Степанович Аренский) (12 July 1861 — 25 February 1906), was a Russian composer of Romantic classical music, a pianist and a professor of music.

Anton Arensky, 1895

Anton Arensky, 1895

Arensky was born in Novgorod, Russia. He was musically precocious and had composed a number of songs and piano pieces by the age of nine. With his mother and father, he moved to Saint Petersburg in 1879, where he studied composition at the Saint Petersburg Conservatory with Nikolai Rimsky-Korsakov. After graduating from the Saint Petersburg Conservatory in 1882, Arensky became a professor at the Moscow Conservatory. Among his students there were Alexander Scriabin, Sergei Rachmaninoff and Alexander Gretchaninov. In 1895 Arensky returned to Saint Petersburg as the director of the Imperial Choir, a post for which he had been recommended by Mily Balakirev. Arensky retired from this position in 1901, spending his remaining time as a pianist, conductor, and composer. Arensky died of tuberculosis in a sanatorium in Perkjärvi, Finland. It is alleged that drinking and gambling undermined his health.

Pyotr Tchaikovsky was the greatest influence on Arensky’s musical compositions. Indeed, Rimsky-Korsakov said, “In his youth Arensky did not escape some influence from me; later the influence came from Tchaikovsky. He will quickly be forgotten.” The perception that he lacked a distinctive personal style contributed to long-term neglect of his music, though in recent years a large number of his compositions have been recorded. Especially popular are the orchestral Variations on a Theme of Tchaikovsky based on one of Tchaikovsky’s Songs for Children, Op. 54.

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this pressed: Selfie tour of Los Angeles – Los Angeles Times


Selfie tour of Los Angeles – Los Angeles Times.

Great Wall of Los Angeles

this pressed: Google Renews Battle With the NSA by Open Sourcing Email Encryption Tool | Enterprise | WIRED


 

Google Renews Battle With the NSA by Open Sourcing Email Encryption Tool | Enterprise | WIRED.
Google Renews Battle With the NSA by Open Sourcing Email Encryption Tool | Enterprise | WIRED.

Google Renews Battle With the NSA by Open Sourcing Email Encryption Tool | Enterprise | WIRED.

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this pressed: Multiple Myeloma: International Myeloma Foundation : • health professionals : imwg conference series : The IMWG Conference Series “Making Sense of Treatment” June 11, 2014


 

Multiple Myeloma: International Myeloma Foundation : • health professionals : imwg conference series : The IMWG Conference Series “Making Sense of Treatment” June 11, 2014.

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this pressed: Verizon tells Netflix to stop blaming it for streaming issues – Los Angeles Times


NetflixVerizon tells Netflix to stop blaming it for streaming issues – Los Angeles Times.

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