Category Archives: News

Drug Reverses Alopecia Areata Hair Loss


Drug Reverses Alopecia Areata Hair Loss

Researchers may have found a cure for the baldness caused by alopecia areata, an autoimmune condition that causes patchy hair loss, and it is a drug already on the market, though for the treatment of bone marrow disorders. After just five months of taking ruxolitinib, three alopecia areata patients who had lost at least a third of their hair due to the disorder saw total hair regrowth. Further testing is needed to see if this treatment will be safe and effective on a wider scale. More… Discuss

this pressed from Reuters: Community Health Systems says personal data stolen in cyber attack | Reuters


Community Health Systems says personal data stolen in cyber attack | Reuters.

today’s holiday: Gabon Independence Day


Gabon Independence Day

Gabon gained official independence from France on August 17, 1960, after more than a century of domination. August 17 is a public holiday, but celebrations often extend to the days before and after Independence Day, with parades and dancing. More… Discuss

Gold as Cancer Fighter


Gold as Cancer Fighter

Alternative medicine proponents have long attributed healing properties to gold, and in recent years, mainstream medical researchers have begun looking to the precious metal as well. In a recent study, tiny gold particles encased in the chemotherapy drug cisplatin appeared to boost the effectiveness of conventional radiotherapy and chemotherapy treatment for an aggressive brain cancer. Cancer cells in samples subjected to this experimental treatment were completely eradicated, and over the next 20 days there was no regrowth. More… Discuss

this pressed From LIBERTY VOICE: Los Angeles Police Shoot Unarmed Black Man


PoliceLos Angeles Police Shoot Unarmed Black Man.

Although the LAPD did not identify the deceased man, his family has come forward in local media to say that he was Ezell Ford, 24. They claim that Ford was mentally ill and that the police were aware of his illness. A spokesman for the LAPD, Cmdr. Andrew Smith, said that although he was aware that the man shot had been arrested in the past, he was unaware why he had been detained and did not know if the department had any knowledge that he suffered from a mental illness
Read more at http://guardianlv.com/2014/08/los-angele-police-shoot-unarmed-man/#b4to72rRAoTE1IjB.99

(Added by Jennifer Pfalz on August 13, 2014.
Saved under California, Crime, Jennifer Pfalz, Los Angeles, U.S.)


Ethicists Unanimously Approve Use of Experimental Ebola Drugs

A panel of ethicists called together by the World Health Organization has unanimously agreed that, given the scope of the current Ebola outbreak and its climbing death toll, it is ethical to offer experimental treatments to the afflicted so long as certain criteria are met. When providing these interventions, the panel insisted, healthcare providers must be transparent about all aspects of patient care. There must be informed consent, freedom of choice, confidentiality, respect for the person, preservation of dignity, and communal involvement. Moreover, health workers are morally obligated to collect and share all data generated from the use of these drugs. More… Discuss

2000 year old tree in South Africa known as tree of life — Earth Pics


this Pressed: What the Democratic Party Does Well: Doing Itself In | Ralph Nader


Ralph Nader at Emory

Ralph Nader at Emory (Photo credit: Wikipedia)

 

(Consumer advocate, lawyer and author)

“My message to Democrats is: Dump your corporate consultants. Just campaign for the necessities of the people. And publicize those Republican votes crisply, widely and repeatedly.”

via What the Democratic Party Does Well: Doing Itself In | Ralph Nader.

Vitamin D Deficiency Linked to Dementia


Vitamin D Deficiency Linked to Dementia

Older adults with severe vitamin D deficiency have an increased risk of developing dementia, a recent study has found. This does not necessarily mean that vitamin D deficiency is a cause of dementia, as it is also possible that another unknown factor could cause someone to have both low vitamin D levels and dementia. Further study is needed to determine the nature of the relationship between vitamin D and dementia, but if it is indeed found to be a causal relationship, it could mean that simply eating more vitamin D-rich foods or taking supplements could reduce dementia risk in later life. More… Discuss

Widget: The News Manual – A professional resource for journalism and the media


News Manual - Truth and freedom (click to access)

News Manual – a professional resource for journalism and the media (click to access)

this pressed-from Science Friday: Giving Viruses a License to Kill…Cancer


Giving Viruses a License to Kill…Cancer.

Giving Viruses a License to Kill…Cancer The lab of Dr. Mark Federspiel at the Mayo Clinic, where the measles virus is being grown in bioreactors for the next clinical trial coming up in September. Photo by Mayo Clinic

this pressed – From BuzzFeed: Commuters Push Train Off Trapped Man


A Perth man slipped and became wedged between a train and the platform at Stirling station on Wednesday afternoon.Commuters Push Train Off Trapped ManCommuters Push Train Off Trapped Man.

this pressed: BBC News – Iraq Christian leader: People are being slaughtered


BBC News – Iraq Christian leader: People are being slaughtered.

today holiday: Jamaica Independence Day


Jamaica Independence Day

The island of Jamaica became an independent nation with loose ties to the British Commonwealth on August 6, 1962. Before that, it had been a founding member of the Federation of the West Indies. Allegiance to the British gradually gave way to the emergence of a national identity, and the federation was dissolved. A public holiday throughout the island, Independence Day is celebrated with a grand parade, traditional music and dancing, arts and crafts exhibits, and agricultural and other events as part of the Jamaica Festival. More… Discuss

today’s birthday: Alexander Fleming (1881)


Alexander Fleming (1881)

English: Alexander Fleming receives the Nobel ...

English: Alexander Fleming receives the Nobel Prize from King Gustaf V of Sweden. (Photo credit: Wikipedia)

 

Motivated by the devastating infections he saw in hospitals during World War I, Fleming, a Scottish bacteriologist, began searching for an effective antiseptic.

English: Chemical structure of Penicillin G. H...

English: Chemical structure of Penicillin G. High-resolution .PNG made with Chem3D and IrfanView — see WikiProject Chemistry – structure drawing for detailed instructions. Please drop me a note if you need the source file. (Photo credit: Wikipedia)

In 1922, he discovered lysozyme, an antibacterial enzyme present in saliva and tears. In 1928, he isolated the substance penicillin, which became the first successful antibiotic for human bacterial infections. His work earned him a Nobel Prize and has forever changed modern medicine. In what accidental way did he discover penicillin? More… Discuss

 

 

The Hot Zone Quotes


The Hot Zone Quotes

The Hot Zone The Hot Zone by Richard Preston

46,786 ratings, 4.06 average rating, 2,291 reviews

buy a copy

The Hot Zone Quotes (showing 1-16 of 16)

“In biology, nothing is clear, everything is too complicated, everything is a mess, and just when you think you understand something, you peel off a layer and find deeper complications beneath. Nature is anything but simple.”
Richard Preston, The Hot Zone

Read all quotations HERE

Tekmira says its Ebola drug not used to treat U.S. aid workers, report – The Globe and Mail


Tekmira says its Ebola drug not used to treat U.S. aid workers, report – The Globe and Mail.

new at EuZicAsa: In the public domain: Pics, Images…WIDGET(access here)


frog-208591_640

Widget: Public domain Images (Access Here)

today’s holiday: Thjodhatid


Thjodhatid

Thjodhatid is a three-day “people’s feast” celebrated in the Vestmannaeyjar area (or Westmann Islands) of Iceland. The festival commemorates the granting of Iceland’s constitution on July 1, 1874; because of foul weather, the island people of Vestmannaeyjar weren’t able to attend the mainland celebration, so they held their own festival at home a month later. Most of the festivities take place on Heimaey Island. Enormous bonfires are built, and there are sporting events, dancing, singing, eating and drinking. People come from the mainland for this event, so the island is filled with campers. More… Discuss

Tunnel (according to Farlex) not to be mistaken for other definitions)


Noun 1. tunnel - a passageway through or under something, usually underground (especially one for trains or cars)tunnel - a passageway through or under something, usually underground (especially one for trains or cars); “the tunnel reduced congestion at that intersection”

auto, automobile, car, motorcar, machine - a motor vehicle with four wheels; usually propelled by an internal combustion engine; “he needs a car to get to work”
 
catacomb - an underground tunnel with recesses where bodies were buried (as in ancient Rome)
 
passageway - a passage between rooms or between buildings
 
railroad tunnel - a tunnel through which the railroad track runs
 
shaft - a long vertical passage sunk into the earth, as for a mine or tunnel
 
underpass, subway - an underground tunnel or passage enabling pedestrians to cross a road or railway
  2. tunnel - a hole made by an animal, usually for sheltertunnel - a hole made by an animal, usually for shelter

hollow, hole - a depression hollowed out of solid matter
 
rabbit warren, warren - a series of connected underground tunnels occupied by rabbits
Verb 1. tunnel - move through by or as by diggingtunnel - move through by or as by digging; “burrow through the forest”

cut into, delve, dig, turn over - turn up, loosen, or remove earth; “Dig we must”; “turn over the soil for aeration”
  2. tunnel - force a way throughtunnel - force a way through                  

penetrate, perforate - pass into or through, often by overcoming resistance; “The bullet penetrated her chest”
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.

The Hanging Gardens of Babylon


The Hanging Gardens of Babylon

The Hanging Gardens were one of the Seven Wonders of the Ancient World. According to legend, Babylonian King Nebuchadnezzar II built the gardens around 600 BCE to soothe his wife, who was homesick for her mountainous homeland. Though extensively documented by ancient historians, no extant Babylonian texts mention the gardens, and there is little physical evidence of their existence. Alternative theories suggest that the gardens were built by the Assyrian king Sennacherib near what modern city? More… Discuss

295 Thought Dead in New Malaysia Airlines Tragedy


295 Thought Dead in New Malaysia Airlines Tragedy

A Malaysia Airlines flight bound for Kuala Lumpur from Amsterdam crashed in eastern Ukraine yesterday, and it may not have been an accident. Ukraine has accused terrorists of shooting down the commercial flight, while the rebels have pointed the finger back at Ukraine. All 295 persons on board—280 passengers and 15 crew—are presumed dead. This is the second tragedy to strike the airline this year. In March, another flight went missing without a trace, and it has yet to be found. More… Discuss

NO WAY: Overpopulation


FROM WIKIPEDIA:  Overpopulation

Population growth that exceeds the carrying capacity of an area or environment results in overpopulation.[21] Spikes in human population can cause problems such as pollution, water crisis,[22][23] and poverty.[24][25] World population has grown from 1.6 billion in 1900 to an estimated 7 billion today. In Mexico alone, population has grown from 13.6 million in 1900 to 107 million in 2007.[26] Virginia Abernethy notes that immigration is a road that provides a “relief valve” to overpopulation that stops a population from addressing the consequences of its overpopulation and that exports this overpopulation to another location or country.[27]

In 2000, the United Nations estimated that the world’s population was growing at the rate of 1.14% (or about 75 million people) per year. According to data from the CIA’s World Factbook, the world human population currently increases by 145 every minute.[28] The United States Census Bureau issued a revised forecast for world population that increased its projection for the year 2050 to above 9.4 billion people, up from 9.1 billion people. There are a billion more added every 12 years. Almost all growth will take place in the less developed regions.[29]

make music part of your life series: Luigi Boccherini – Guitar Quintet in D major, G. 449 – IV. Andantino pausato con variazioni


Luigi Boccherini – Guitar Quintet in D major, G. 449 – IV. Andantino pausato con variazioni

Published on Jun 13, 2012

Zoltán Tokos, guitar. Danubius String Quartet. Judit Tóth, violin. Adél Miklós, violin. Eniko Nagy, viola. Ilona Ribli, cello.

Saint of the Day for Wednesday, July 16th, 2014: St. Carmen (Patronal Feast Day )


tghis day in the yesteryear: Shoemaker-Levy 9 Comet Collides with Jupiter (1994)


Shoemaker-Levy 9 Comet Collides with Jupiter (1994)

In March 1993, astronomers Carolyn and Eugene Shoemaker and David Levy made the first observation of a comet orbiting a planet rather than the Sun. Sixteen months later, fragments of the comet collided with Jupiter’s southern hemisphere, providing the first direct observation of the collision of two solar system objects. The impact left prominent scars that some said were more easily visible than the planet’s Great Red Spot. How did the event highlight Jupiter’s role as “cosmic vacuum cleaner“? More… Discuss

BBC News – In pictures: Rounding-up of wild horses in Galicia, Spain


 

BBC News – In pictures: Rounding-up of wild horses in Galicia, Spain.

Israeli commandos clash with Hamas gunmen in Gaza raid | Reuters


Israeli commandos clash with Hamas gunmen in Gaza raid | Reuters.

In Malaysia, Islam’s legal advance divides families and nation | Reuters


 

In Malaysia, Islam’s legal advance divides families and nation | Reuters.

Shocking!


Shocking!

The evolution of electric fish has long fascinated scientists, in part because the feature developed independently in six different groups of fish in disparate regions of the globe. Despite differences in the appearance and locations of these creatures’ electric organs, DNA evidence now shows that the genetic and biological pathways that brought about their electrification are the same in many if not all electric fish. More… Discuss

Espresso Machine’s Out-of-This-World Launch


Espresso Machine’s Out-of-This-World Launch

Coffee lovers of the world—nay, universe—rejoice! You will now be able to get a decent cup of joe in space. After decades of drinking subpar java, astronauts will finally have access to real Italian espresso in orbit. Engineers partnered with coffee giant Lavazza to design an espresso machine suitable for use on the International Space Station (ISS). The 44-pound (20-kg) “ISSpresso” machine is set to launch early next year on a cargo ship bound for the ISS, where Samantha Cristoforetti, Italy‘s first female astronaut, will also serve as the first space barista. More… Discuss

Video Calls Benefit Some Hospitalized Children


Video Calls Benefit Some Hospitalized Children

“Virtual visits” with loved ones help reduce stress for some—but not all—hospitalized children. Having access to video chat technology reduced stress levels for kids who lived an average of 35 miles from the hospital and were only hospitalized for about five days. However, pediatric patients whose hospital stays were longer or whose families lived farther away saw no real stress-reducing benefit from the technology. More… Discuss

this pressed: The NSA Revelations All in One Chart


ProPublica: The NSA Revelations All in One Chart
ProPublica: The NSA Revelations All in One Chart

via The NSA Revelations All in One Chart. (ProPublica)

health: “Drastic Action” Needed to Contain Ebola Outbreak in West Africa


“Drastic Action” Needed to Contain Ebola Outbreak in West Africa

The World Health Organization is calling for “drastic action” to contain the outbreak of Ebola currently raging in West Africa. Since the outbreak began four months ago, it has spread from Guinea to nearby Sierra Leone and Liberia, infected more than 600 people, and claimed nearly 400 lives, making it the largest Ebola outbreak in terms of cases, deaths, and geographical spread. Despite the presence of 150 experts, the number of reported cases and deaths is still rising daily, threatening the entire region and beyond. The charity Médecins Sans Frontières, or Doctors Without Borders, says the outbreak is out of control. More… Discuss

this pressed: Google I/O – What We Now Know – Forbes (google should use the profits in a socially responsible manner e.g. why not invest in nanothechnology to help the autoimune system fight, conquer and eradicate Multiple Myeloma ? instead of stupid robots?)


Google I/O: What We Now Know – Forbes.

make music part of your life series: Singer-songwriter Val Ghent at Cornelia Street Cafe Night of the Killer Keyboarders


Singer-songwriter Val Ghent @ Cornelia Street Cafe Night of the Killer Keyboarders

Day to Day Dream.http://www.valghent.com/ “Present Day Funk Sister” Valerie Ghent With Her Brothers Clayton Bryant, Tinker Barfield & Robin Macatangay. valghent.com

UNRELIABLE applications: if all other appications would be as bad we would not have an INTERNET: I’d saqy why fix it create new applications, accept them, and demonololize! this is ridiculously sad!


Adobe Flash & Shockwave - Mizarable applications - Why are we stuck with them

Adobe Flash & Shockwave – Unreliable applications – Why are we stuck with them

Adobe Shockwave Player Logo

Adobe Shockwave Player Logo (Photo credit: Wikipedia)

“A Plug-in (Shockwave Flash) isn’t responding” “Stop Plug-in.”

17 posts by 13 authors

All you hear for years is troubleshoot, is the browser, is the this and that.:  no it’s these two applications! 

Gnome-mime-application-x-shockwave-flash

Gnome-mime-application-x-shockwave-flash (Photo credit: Wikipedia)

Grapefruit–drug interactions From wikipedia (and other sources)


Grapefruit–drug interactions

From Wikipedia, the free encyclopedia
 

Grapefruit and grapefruit juice have been found to interact with numerous drugs (at least 85 by the latest[when?] count), in many cases resulting in adverse effects.[1] Organic compounds that are furanocoumarin derivatives interfere with the hepatic and intestinal enzyme cytochrome P450 isoform CYP3A4 and are believed to be primarily responsible for the effects of grapefruit on the enzyme. Bioactive compounds in grapefruit juice may also interfere with P-glycoprotein and organic anion transporting polypeptides (OATPs), either increasing or decreasing the bioavailability of a number of drugs. Pomelo (the Asian fruit which was crossed with an orange to produce grapefruit) also contains high amounts of furanocoumarin derivatives. Some grapefruit-pomelo hybrids have practically no furanocoumarin content, and one is a commercially viable seedless type.[2]

Affected drugs

The following drugs are affected by CYP3A4 inhibition with grapefruit compounds:

 

Amphetamines

List of Amphetamines That Interact With The Cytochrome P450 CYP2D6 enzyme:

Research has been done on the interaction between amphetamines and The Cytochrome P450 CYP2D6 enzyme, and researchers concluded that some parts of substrate molecules contribute to the binding of the enzyme. [11]

 

Additional drugs found to be affected by grapefruit juice include, but are not limited to:

Mechanism of the interaction

The CYP3A4 isoform of cytochrome P450 is located in both the liver and the enterocytes. Many oral drugs undergo first-pass (presystemic) metabolism by the enzyme. Several organic compounds found in grapefruit and specifically in grapefruit juice exert inhibitory action on drug metabolism by the enzyme. It has been established that a group of compounds called furanocoumarins are responsible for this interaction, and not flavonoids as was previously reported.[32] The list of active furanocoumarins found in grapefruit juice includes: bergamottin, bergapten, bergaptol and 6′,7′-dihydroxybergamottin.

This interaction is particularly dangerous when the drug in question has a low therapeutic index, so that a small increase in blood concentration can be the difference between therapeutic effect and toxicity. Grapefruit juice inhibits the enzyme only within the intestines, not in the liver or elsewhere in the body, and does not impact injected drugs. The degree of the effect varies widely between individuals and between samples of juice, and therefore cannot be accounted for a priori.

Another mechanism of interaction is possibly through the P-glycoprotein (Pgp) that is localized in the apical brush border of the enterocytes. Pgp transports lipophilic molecules out of the enterocyte back into the intestinal lumen. Drugs that possess lipophilic properties are either metabolised by CYP3A4 or removed into the intestine by the Pgp transporter. Both the Pgp and CYP3A4 may act synergistically as a barrier to many orally administered drugs. Therefore, their inhibition (both or alone) can markedly increase the bioavailability of a drug.

The interaction caused by grapefruit compounds lasts for up to 72 hours, and its effect is the greatest when the juice is ingested with the drug or up to 4 hours before the drug. [33][34][35]

Drugs affected by grapefruit juice[36]
Drug class Major Interactions Minor interactions
Antiarrhythmic agents amiodarone (Cordarone)
dronedarone (Multaq)
 
Antihistamines terfenadine (Seldane) (off the market)
diphenhydramine (Benadryl) (partially)
astemizole (Hismanal) (off the market)
 
Calcium channel antagonists   felodipine (Plendil)
nicardipine (Cardene)
nifedipine (Procardia)
nimodipine (Nimotop)
nisoldipine (Sular)
isradipine (DynaCirc)
Cholesterol-lowering drugs aka
Statins (HMG-CoA reductase inhibitors)
simvastatin (Zocor)
lovastatin (Mevacor)
atorvastatin (Lipitor)
cerivastatin (Baycol) (off the market)
Cough Suppressant/NMDA Antagonist dextromethorphan  
Erectile dysfunction drugs   sildenafil (Viagra)
tadalafil (Cialis)
vardenafil (Levitra)
HIV protease inhibitors   saquinavir (Invirase)
ritonavir (Norvir)
nelfinavir (Viracept)
amprenavir (Agenerase)
Hormones   ethinyl estradiol (Ortho-Cept, many others)
methylprednisolone (Medrol)
Immunosuppressants   cyclosporine (Sandimmune, Neoral)
tacrolimus (Prograf)
sirolimus (Rapamune)
mercaptopurine
Sedatives, hypnotics, and anxiolytics buspirone (Buspar) triazolam (Halcion)
midazolam (Versed)
diazepam (Valium)
zaleplon (Sonata)
alprazolam (Xanax)
Other psychotropics   carbamazepine (Tegretol)
trazodone (Desyrel)
quetiapine (Seroquel)
fluvoxamine (Luvox)
nefazodone (Serzone) (off the market)
Other miscellaneous drugs cisapride (Prepulsid, Propulsid)[37]  

References

  1. Bailey, David G.; Dresser, George; Arnold, J. Malcolm O. (2012). “Grapefruit-medication interactions: Forbidden fruit or avoidable consequences?”. Canadian Medical Association Journal (Canadian Medical Association). doi:10.1503/cmaj.120951. edit
  2. “– Hybrid grapefruit safe for prescription meds”. Futurity.org. Retrieved 2013-01-28.
  3. Template:Cite pubmed.gov
  4. Sugimoto K, Araki N, Ohmori M, et al. (2006). “Interaction between grapefruit juice and hypnotic drugs: comparison of triazolam and quazepam”. Eur. J. Clin. Pharmacol. 62 (3): 209–15. doi:10.1007/s00228-005-0071-1. PMID 16416305.
  5. “Ritonavir (Norvir)”. HIV InSite. UCSF. 2006-10-18. Retrieved 2008-03-12.
  6. Lee AJ, Chan WK, Harralson AF, Buffum J, Bui BC. (1999). “The effects of grapefruit juice on sertraline metabolism: an in vitro and in vivo study.”. Clin Ther. 21 (11): 1890–9. doi:10.1016/S0149-2918(00)86737-5. PMID 10890261.
  7. “Interactions of amphetamine analogs with human liver CYP2D6″. National Center for Biotechnology Information, U.S. National Library of Medicine.
  8. “SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions.”. Structural Bioinformatics Group, Institute of Physiology, Charité-University Medicine Berlin.
  9. “Methamphetamine-mediated oxidative stress induces astrocyte apoptosis via cytochrome P450 2E1″. National Center for Biotechnology Information, U.S. National Library of Medicine.
  10. “potent inhibition of P450 gene CYP2D6 on d-amphetamine, methylphenidate, and cocaine”. Department of Pharmacology, University of Toronto, Ontario, Canada.
  11. “Metabolism/ Metabolites of amphetamines interacting with The Cytochrome P450 CYP2D6 enzyme”. U.S. National Library of Medicine.
  12. Bailey DG, Dresser GK (2004). “Interactions between grapefruit juice and cardiovascular drugs”. Am J Cardiovasc Drugs 4 (5): 281–97. doi:10.2165/00129784-200404050-00002. PMID 15449971.
  13. Lilja JJ, Kivistö KT, Neuvonen PJ (August 1999). “Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin”. Clin. Pharmacol. Ther. 66 (2): 118–27. doi:10.1053/cp.1999.v66.100453001. PMID 10460065.
  14. Lilja JJ, Kivistö KT, Backman JT, Lamberg TS, Neuvonen PJ (1998). “Grapefruit juice substantially increases plasma concentrations of buspirone*”. Clinical Pharmacology & Therapeutics 64 (6): 655–660. doi:10.1016/S0009-9236(98)90056-X. PMID 9871430. edit
  15. Lilja, JJ; Laitinen, K; Neuvonen, PJ (September 2005). “Effects of grapefruit juice on the absorption of levothyroxine.”. British Journal of Clinical Pharmacology 60 (3): 337–41. doi:10.1111/j.1365-2125.2005.02433.x. PMC 1884777. PMID 16120075.
  16. Jetter A, Kinzig-Schippers M, Walchner-Bonjean M, et al. (2002). “Effects of grapefruit juice on the pharmacokinetics of sildenafil”. Clin. Pharmacol. Ther. 71 (1): 21–9. doi:10.1067/mcp.2002.121236. PMID 11823754.
  17. H. Hori, R. Yoshimura, N. Ueda, S. Eto, K. Shinkai, S. Sakata, O. Ohmori, T. Terao and J. Nakamura (2004). “Fluvoxamine, In Vivo Study” (PDF). J Clin Psychopharmacol 23 (4): 422–424. doi:10.1097/01.jcp.0000085423.74359.f2. PMID 12920426.
  18. Gasche Y, Daali Y, Fathi M, et al. (December 2004). “Codeine intoxication associated with ultrarapid CYP2D6 metabolism”. N. Engl. J. Med. 351 (27): 2827–31. doi:10.1056/NEJMoa041888. PMID 15625333. Retrieved 2008-05-11.
  19. Further characterization of a furanocoumarin-free grapefruit juice on drug disposition: studies with cyclosporine“, American Journal of Clinical Nutrition, Vol. 87, No. 4, 863-871, April 2008.
  20. [1] “Somelabel”
  21. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014525/ Mouly and Paine, Br J Clin Pharmacol. 2001 August; 52(2): 216–217.
  22. “Grapefruit and medication: A cautionary note”. Health.harvard.edu. Retrieved 2013-01-28.
  23. Wikipedia article on oxycodone metabolism; pharmaceutical insert w/ Purdue OxyContin tablets – http://en.wikipedia.org/wiki/Oxycodone#Metabolism
  24. “Grapefruit Interactions”. healthCentral. Retrieved 2013-01-28.
  25. Messaoud Benmebarek MD, Et al., M; Devaud, C; Gex-Fabry, M; Powell Golay, K; Brogli, C; Baumann, P; Gravier, B; Eap, CB (17 March 2004). “Effects of grapefruit juice on the pharmacokinetics of the enantiomers of methadone”. Clinical Pharmacology & Therapeutics 76 (1): 55–63. doi:10.1016/j.clpt.2004.03.007. PMID 15229464. Retrieved 2009-03-13.
  26. Elkader, A; Sproule, B (July 2005). “Bluprenorphine – Clinical pharmacokinetics in the treatment of opioid dependence”. Clinical Pharamacokinetics 44 (7): 661–680. doi:10.2165/00003088-200544070-00001. PMID 15966752. Retrieved 2013-02-24.
  27. [2][dead link]
  28. “HIGHLIGHTS OF PRESCRIBING INFORMATION”. Gene. Retrieved 2013-01-28.
  29. Dasgupta, Amitava; Meredith A. Reyes; Semyon A. Risin; Jeffrey K. Actor (3 December 2008). “Interaction of white and pink grapefruit juice with acetaminophen (paracetamol) in vivo in mice”. Journal of Medicinal Food 11 (4): 795–8. doi:10.1089/jmf.2008.0059. ISSN 1557-7600. PMID 19053875.
  30. Dresser, GK; Kim RB; Bailey DG (March 2005). “Effect of grapefruit juice volume on the reduction of fexofenadine bioavailability: possible role of organic anion transporting polypeptides.”. Clinical Pharmacological Therapeutics 77 (3): 170–7. PMID 15735611.
  31. Jellin J.M., et al. Pharmacist’s Letter/Prescriber’s Letter of Natural Medicines Comprehensive Database. 7th ed. Stockton, CA: Therapeutic Research Faculty. 2005. 626-629
  32. Paine MF, Widmer WW, Hart HL, et al. (May 2006). “A furanocoumarin-free grapefruit juice establishes furanocoumarins as the mediators of the grapefruit juice-felodipine interaction”. The American journal of clinical nutrition 83 (5): 1097–105. PMID 16685052.
  33. Lundahl J, Regardh CG, Edgar B, Johnsson G. Relationship between time of intake of grapefruit juice and its effect on pharmacokinetics and pharmacodynamics of felodipine in healthy subjects. Eur J Clin Pharmacol 1995;49:61-7.
  34. http://pharmacistanswers.com/grapefruit-juice-drug-interactions.html
  35. Greenblatt DJ, von Moltke LL, Harmatz JS, et al. Time course of recovery of cytochrome P450 3A function after single doses of grapefruit juice. Clin Pharmacol Ther 2003;75:121-9.
  36. Bakalar, Nicholas (2006-03-21). “Experts Reveal the Secret Powers of Grapefruit Juice”. The New York Times. p. F6. Retrieved 2008-05-21.
  37. Gross AS, Goh YD, Addison RS, Shenfield GM (April 1999). “Influence of grapefruit juice on cisapride pharmacokinetics”. Clin. Pharmacol. Ther. 65 (4): 395–401. doi:10.1016/S0009-9236(99)70133-5. PMID 10223776.

External links

 

UC Davis MIND Institute Study Finds Association Between Maternal Exposure to Agricultural Pesticides, Autism in Offspring



UC Davis MIND Institute Study Finds Association Between Maternal Exposure to Agricultural Pesticides, Autism in Offspring
.

mindinstitute.ucdavis.edu

Source: http://www.ucdmc.ucdavis.edu
The work was supported by grants from the National Institute of Environmental Health Sciences R01-ES015359, P01-ES011269 and U.S. Environmental Protection Agency Science to Achieve Results (STAR) grants R833292 and 829338. The study is available free of charge at:  http://ehp.niehs.nih.gov/1307044/

Mojave Desert


Mojave Desert

The Mojave Desert occupies a significant portion of southeastern California and parts of Utah, Nevada, and Arizona. It is named for the Mojave tribe of Native Americans, who made it their home. It is also home to the world’s largest Joshua tree forest and the third-tallest dunes in North America, the 600-foot-high Kelso Dunes. The desert’s Death Valley, the lowest, hottest, driest area of North America, has recorded some of the world’s highest air temperatures. What is the Mojave’s largest city? More… Discuss

WORLDTRUTHTV: REDEFINING 1% (DOES REBLOGGING REALLY CHANGE ANYTHING?)


WORLDTRUTHTV-REDEFING 1%

WORLDTRUTHTV-REDEFING 1%

Violent and Legal: The Shocking Ways School Kids are Being Pinned Down, Isolated Against Their Will – ProPublica


Violent and Legal: The Shocking Ways School Kids are Being Pinned Down, Isolated Against Their Will – ProPublica.

6 Awesome Alternatives to YouTube – The Next Web


 

6 Awesome Alternatives to YouTube – The Next Web.

Study finds link between pesticides and autism – Yahoo News


A California study finds that pregnant women who live near farms where pesticides are applied have a two-thirds higher risk of having children with autism (AFP Photo/Philippe Huguen)

A California study finds that pregnant women who live near farms where pesticides are applied have a two-thirds higher risk of having children with autism (AFP Photo/Philippe Huguen)

Study finds link between pesticides and autism – Yahoo News.

Refugee Numbers Highest Since World War II (51, 000, 000 people forced to leave their homes: shame on the world leaders and ONU!)


Refugee Numbers Highest Since
World War II

The number of refugees worldwide has risen to levels not seen since World War II. There are an estimated 51.2 million people now displaced from their homes by conflict and persecution. Of these, 6.3 million have been living in “protracted” refugee situations, meaning they have been refugees for years, even decades. The surge in refugees is straining available resources and destabilizing some of the countries to which they have fled. More… Discuss

Bad Pass Lands Man in Jail


Bad Pass Lands Man in Jail

Let this story be a lesson to any would-be contraband smugglers—do not try to toss a football filled with heroin, marijuana, tobacco, cell phones, and chargers over a prison fence unless you are certain you have the arm for it. A young man in Michigan is now behind bars and facing contraband charges after allegedly attempting this feat and failing, his football landing short between two fences at a state prison rather than in the inmates’ exercise yard. Not only did the boneheaded criminal fail to make his delivery, but he also attempted it in full view of one of the prison’s guards and was quickly apprehended. More… Discuss

Possible Mass Anthrax Exposure at CDC Labs (loosing the grip on reality?)


Possible Mass Anthrax Exposure at CDC Labs

As many as 75 scientists working in US federal government laboratories in Atlanta, Georgia, may have been accidentally exposed to live anthrax bacteria after staff members at a high-level facility failed to follow proper procedures to inactivate the deadly bacteria before sending the samples to lower-level labs for experimentation. The US Centers for Disease Control and Prevention, under whose watch the breach occurred, is now investigating the incident and is offering antibiotic treatment and vaccines to those who might have been exposed. More… Discuss

article: The Baths of Bath


The Baths of Bath

Bath is a city in southwest England famous for its baths, which are fed by the only natural hot springs in the country and which some believe have curative properties. The Romans established the city as Aquae Sulis in the first century, building elaborate, lead-lined baths with heating and cooling systems. These were rediscovered in 1755, by which time Bath, as it had since become known, had revived as a spa and become a resort city for the wealthy. What was Jane Austen‘s connection to Bath? More… Discuss

today’s holiday: Carberry Day


Carberry Day

The students and faculty at Brown University in Providence, Rhode Island, celebrate the fictitious academic exploits of Professor Josiah Stinkney Carberry every Friday the 13th. On Carberry Day, small brown jugs appear around campus, and students and teachers fill them with change. The money goes to a book fund that Professor Carberry has set up “in memory of my future late wife, Laura.” More… Discuss

Insurgents Take Second Iraqi City


Insurgents Take Second Iraqi City

Insurgents from the Islamic State of Iraq and the Levant (ISIS), an offshoot of al-Qaeda several thousand fighters strong that controls considerable territory in eastern Syria and western and central Iraq, have attacked cities around western and northern Iraq this week and taken two of them, Mosul and Tikrit. As many as 500,000 people fled Mosul after the city was attacked. Even security forces reportedly fled. But government leaders have vowed to repel the militants. More… Discuss