[youtube.com/watch?v=BZ53kQKjxek]
I Allegro moderato
II Poco adagio
III Moderato innocente
Paolo Restani, piano
Orchestre Philharmonique de Nice
Marco Guidarini, conductor
I Allegro moderato
II Poco adagio
III Moderato innocente
Paolo Restani, piano
Orchestre Philharmonique de Nice
Marco Guidarini, conductor
Posted in Educational, IN THE SPOTLIGHT, MEMORIES, PEOPLE AND PLACES HISTORY, GEOGRAPHY, Uncategorized, YouTube/SoundCloud: Music, Special Interest
Tagged JOHN FIELD, Make Music Part of Your Life Series, Orchestre Philharmonique de Nice Marco Guidarini, Paolo Restani, Piano, Piano concerto, Piano Concerto No. 2
Evil never dies: I am so very sorry for what happens in Ukraine and the “terrorism” that is called anything else but what it really is!
Posted in Uncategorized
facebook: not a happy face at all!
[youtube.com/watch?v=uBpyjUd_8Qk] | |
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Orquesta de la Ciudad de los Reyes Director: Pablo Sabat |
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Auditorio del Colegio Santa Ursula Lima – Peru, 10 Diciembre 2009 |
Posted in IN THE SPOTLIGHT, PEOPLE AND PLACES HISTORY, GEOGRAPHY, YouTube/SoundCloud: Music, Special Interest
Tagged Alphonse Daudet, Arts -Architecture, sculpture, Carmen, Christopher Wheeldon, Eric Rochefort, georges bizet, Google, L'Arlésienne, L'Arlesienne Suite, Lucas Vandel, Marc Brunet, Olivier Cherki, Pierre Michel, Viviane Yen
William of Vercelli, Saint 1085-1142. founder, born in Vercelli Italy he was brought up as an orphan became a hermit on Monte Vergine, Italy after a pilgrimage to Compostella and attracted so many … continue reading
Posted in Educational, IN THE SPOTLIGHT, PEOPLE AND PLACES HISTORY, GEOGRAPHY, SPIRITUALITY, Uncategorized
Tagged Compostella, God, Italy, Jesus, Monte Vergine, Saint of the Day St. William of Vercelli, Vercelli, Vercelli Italy, William of Montevergine, William of Vercelli, William of Vercelli St. Adalbert St. Dominic Henares St. Eurosia St. Gallicanus St. Gohardus St. Maximus
Croatians mark this national holiday to commemorate the country‘s declaration of independence from Yugoslavia on June 25, 1991. This holiday is distinct from the country’s Independence Day on October 8, when the implementation of the declaration went into effect. Offices, businesses, and schools are closed in Croatia on Statehood Day. Wreaths are laid and candles lit at sites of fallen soldiers, including the graves of national heroes. Past celebrations have included a ceremonial line-up of military troops in the central square of the country’s capital, Zagreb, and speeches by the country’s leaders. More… Discuss
Flash Shockingly Proprietary only source of daily misery for computer users everywhere
Adobe Flash & Shockwave – Unreliable applications – Why are we stuck with them
Posted in Educational, FILM, MY TAKE ON THINGS, News, ONE OF MY FAVORITE THINGS, PEOPLE AND PLACES HISTORY, GEOGRAPHY, Uncategorized, YouTube/SoundCloud: Music, Special Interest
Tagged Adobe Flash, Adobe Flash Player, Adobe Shockwave, Adobe Systems, Microsoft Windows, Patch (computing), Shockwave Flash, vulnerability
The road to the City of Emeralds is paved with yellow brick.
L. Frank Baum (1856-1919) Discuss
Posted in BOOKS, Educational, IN THE SPOTLIGHT, MEMORIES, MY TAKE ON THINGS, PEOPLE AND PLACES HISTORY, GEOGRAPHY, Uncategorized
Tagged City of Emeralds, Cowardly Lion, Dorothy Gale, Emerald City, L. Frank Baum, the yellow brick road, Wicked Witch of the West, Wizard of Oz, Wonderful Wizard of Oz, yellow brick, Yellow brick road
Carly Simon is an American musician who emerged as one of the leading artists of the early 1970s singer-songwriter boom. Her 1988 hit “Let the River Run,” featured in the movie Working Girl, earned her a Grammy, an Oscar, and a Golden Globe, yet it is not her most famous song. This distinction goes to “You’re So Vain,” a sarcastic profile of a self-absorbed lover. A number-one hit, it spawned a huge debate as to who inspired the lyrics. Who are some of the possible candidates? More… Discuss
[youtube.com/watch?v=cv-0mmVnxPA]
Lyrics, Liner Notes, Credits, DVD, CD, Rare Photos at Carly’s official website:
http://www.carlysimon.com/music/Worki…
From the 1989 soundtrack of Working Girl.
Carly won an Oscar and a Golden Globe for this song.
Hyde was an Irish scholar and political leader. He was largely responsible for the revival of Irish language and literature through his founding of the Gaelic League in 1893. After teaching modern Irish for many years, Hyde became the president of Ireland, or Eire, in 1938. Using his Gaelic name, An Craoibhin Aoibhinn, he authored many works, including Literary History of Ireland and Love Songs of Connacht. A polyglot, Hyde was fluent in how many languages? More… Discuss
Posted in Educational, IN THE SPOTLIGHT, PEOPLE AND PLACES HISTORY, GEOGRAPHY, Uncategorized
Tagged Conradh na Gaeilge, Douglas Hyde, Douglas Hyde Elected First President of Ireland, Gaelic Athletic Association, Gaelic League, Gaelic scholar, History of Ireland, Hyde, Ireland, Irish, Irish language, Irish language and literature, Irish scholar, President of Ireland
A weeklong Federal Bureau of Investigation (FBI) sting operation spanning the US has led to the arrest of 281 pimps and the rescue of 168 children from sex traffickers. Approximately 400 law enforcement agencies in over 100 cities took part in Operation Cross Country VIII, part of the FBI’s Innocence Lost National Initiative, which, since its inception in 2003, has recovered approximately 3,600 children and gained 1,450 convictions against those exploiting them. More… Discuss
Posted in Educational, IN THE SPOTLIGHT, PEOPLE AND PLACES HISTORY, GEOGRAPHY, Uncategorized
Tagged Children, Cross country running, FBI, Federal Bureau of Investigation, Human trafficking, James B. Comey, law enforcement agencies, Law enforcement agency, National Center for Missing & Exploited Children, Sex Trafficking, sting operation, United States
Definition: | (adjective) Excessively unwilling to spend. |
Synonyms: | penurious |
Usage: | I had to sue my parsimonious landlord for not giving me enough heat this winter. Discuss. |
Grapefruit and grapefruit juice have been found to interact with numerous drugs (at least 85 by the latest[when?] count), in many cases resulting in adverse effects.[1] Organic compounds that are furanocoumarin derivatives interfere with the hepatic and intestinal enzyme cytochrome P450 isoform CYP3A4 and are believed to be primarily responsible for the effects of grapefruit on the enzyme. Bioactive compounds in grapefruit juice may also interfere with P-glycoprotein and organic anion transporting polypeptides (OATPs), either increasing or decreasing the bioavailability of a number of drugs. Pomelo (the Asian fruit which was crossed with an orange to produce grapefruit) also contains high amounts of furanocoumarin derivatives. Some grapefruit–pomelo hybrids have practically no furanocoumarin content, and one is a commercially viable seedless type.[2]
The following drugs are affected by CYP3A4 inhibition with grapefruit compounds:
List of Amphetamines That Interact With The Cytochrome P450 CYP2D6 enzyme:
Research has been done on the interaction between amphetamines and The Cytochrome P450 CYP2D6 enzyme, and researchers concluded that some parts of substrate molecules contribute to the binding of the enzyme. [11]
Additional drugs found to be affected by grapefruit juice include, but are not limited to:
The CYP3A4 isoform of cytochrome P450 is located in both the liver and the enterocytes. Many oral drugs undergo first-pass (presystemic) metabolism by the enzyme. Several organic compounds found in grapefruit and specifically in grapefruit juice exert inhibitory action on drug metabolism by the enzyme. It has been established that a group of compounds called furanocoumarins are responsible for this interaction, and not flavonoids as was previously reported.[32] The list of active furanocoumarins found in grapefruit juice includes: bergamottin, bergapten, bergaptol and 6′,7′-dihydroxybergamottin.
This interaction is particularly dangerous when the drug in question has a low therapeutic index, so that a small increase in blood concentration can be the difference between therapeutic effect and toxicity. Grapefruit juice inhibits the enzyme only within the intestines, not in the liver or elsewhere in the body, and does not impact injected drugs. The degree of the effect varies widely between individuals and between samples of juice, and therefore cannot be accounted for a priori.
Another mechanism of interaction is possibly through the P-glycoprotein (Pgp) that is localized in the apical brush border of the enterocytes. Pgp transports lipophilic molecules out of the enterocyte back into the intestinal lumen. Drugs that possess lipophilic properties are either metabolised by CYP3A4 or removed into the intestine by the Pgp transporter. Both the Pgp and CYP3A4 may act synergistically as a barrier to many orally administered drugs. Therefore, their inhibition (both or alone) can markedly increase the bioavailability of a drug.
The interaction caused by grapefruit compounds lasts for up to 72 hours, and its effect is the greatest when the juice is ingested with the drug or up to 4 hours before the drug. [33][34][35]
Posted in Educational, Fitness, running, biking, outdoors, FOOD AND HEALTH, Health and Environment, News, PEOPLE AND PLACES HISTORY, GEOGRAPHY, Uncategorized
Tagged Bitter orange, Canadian Medical Association Journal, Furanocoumarin, Grapefruit, Grapefruit juice, Lawson Health Research Institute, Prescription medication, wikipedia