Daily Archives: March 6, 2017

Breaza Făgăraşului: “Nuşcele”


Breaza Făgăraşului: “Nuşcele”

Today’s Holiday:Alamo Day


Today’s Holiday:
Alamo Day

In 1836, a garrison of Texans took a stand against the Mexican Army at a Franciscan mission in San Antonio, named after the grove of cottonwood trees (alamo in Spanish) that surrounded it. Led by William Barret Travis, the band of volunteers was beseiged for 13 days by Mexican soldiers. Travis refused to surrender, and the Alamo was overrun on the morning of March 6. Only women and children survived. The heroic action at the Alamo gave the Texans time to organize the forces necessary to save their independence movement. More…: https://play.google.com/store/apps/details?id=com.tfd.mobile.TfdSearch

Today’s Birthday:Louis Francis “Lou” Costello (1906)


Today’s Birthday:
Louis Francis “Lou” Costello (1906)

Costello was an American comedian who, along with Bud Abbott, formed the comedic duo of Abbott and Costello. From 1931 to 1957, Costello played a bumbling, cheery dimwit alongside Abbott’s “straight man” in various stage, radio, and TV routines, the most famous of which was their “Who’s on First?” skit. Regarded as the archetypal team of burlesque comedy, the pair starred in movies such as Buck Privates and Abbott & Costello Meet Frankenstein. Why did the two eventually part ways? More…: https://play.google.com/store/apps/details?id=com.tfd.mobile.TfdSearch

This Day in History:Walter Cronkite Signs off CBS Evening News (1981)


This Day in History:
Walter Cronkite Signs off CBS Evening News (1981)

During his career as a broadcast journalist, “Uncle Walter,” as Cronkite was affectionately known, was identified in public opinion polls as the most trusted man in America. He was managing editor and anchorman of The CBS Evening News with Walter Cronkite for almost 20 years and covered the first televised US presidential election, the 1969 moon landing, and the assassination of US President John F. Kennedy. In 1981, he signed off for the last time with what famous phrase? More…: https://play.google.com/store/apps/details?id=com.tfd.mobile.TfdSearch

Quote of the Day:Alexander Hamilton


Quote of the Day:
Alexander Hamilton

Constitutions should consist only of general provisions; the reason is that they must necessarily be permanent, and that they cannot calculate for the possible change of things. More…: https://play.google.com/store/apps/details?id=com.tfd.mobile.TfdSearch

Article of the Day:Amblypoda


Article of the Day:
Amblypoda

Though few authorities include Amblypoda in modern classifications, scientists once defined it as a group of extinct, herbivorous mammals common to North America during the Tertiary period. Once considered a suborder of primitive ungulates, or hoofed mammals, experts have since concluded that members do not share a common ancestor. They do agree, however, that the group’s members had very small brain cavities relative to their mass. From what physical characteristic is the group’s name derived? More…: https://play.google.com/store/apps/details?id=com.tfd.mobile.TfdSearch

Idiom of the Day:the honest truth


Idiom of the Day:
the honest truth

The sincere, unadulterated truth. Watch the video…: https://play.google.com/store/apps/details?id=com.tfd.mobile.TfdSearch

Word of the Day:worriment


Word of the Day:
worriment

Definition: (noun) A difficulty that causes anxiety.
Synonyms: troublesomeness, inconvenience
Usage: To him, everything was a worriment, and his anxiety increased every day.: https://play.google.com/store/apps/details?id=com.tfd.mobile.TfdSearch

The New England Journal of Medicine: Gene Therapy in a Patient with Sickle Cell Disease


The New England Journal of Medicine: Gene Therapy in a Patient with Sickle Cell Disease

<br /><a href="http://www.nejm.org/doi/10.1056/NEJMoa1609677">this is a shotcut to the article</a>

Gene Therapy in a Patient with Sickle Cell Disease
Jean-Antoine Ribeil, M.D., Ph.D., Salima Hacein-Bey-Abina, Pharm.D., Ph.D., Emmanuel Payen, Ph.D., Alessandra Magnani, M.D., Ph.D., Michaela Semeraro, M.D., Ph.D., Elisa Magrin, Ph.D., Laure Caccavelli, Ph.D., Benedicte Neven, M.D., Ph.D., Philippe Bourget, Pharm.D., Ph.D., Wassim El Nemer, Ph.D., Pablo Bartolucci, M.D., Ph.D., Leslie Weber, M.Sc., Hervé Puy, M.D., Ph.D., Jean-François Meritet, Ph.D., David Grevent, M.D., Yves Beuzard, M.D., Stany Chrétien, Ph.D., Thibaud Lefebvre, M.D., Robert W. Ross, M.D., Olivier Negre, Ph.D., Gabor Veres, Ph.D., Laura Sandler, M.P.H., Sandeep Soni, M.D., Mariane de Montalembert, M.D., Ph.D., Stéphane Blanche, M.D., Philippe Leboulch, M.D., and Marina Cavazzana, M.D., Ph.D.
N Engl J Med 2017; 376:848-855March 2, 2017DOI: 10.1056/NEJMoa1609677

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Sickle cell disease results from a homozygous missense mutation in the β-globin gene that causes polymerization of hemoglobin S. Gene therapy for patients with this disorder is complicated by the complex cellular abnormalities and challenges in achieving effective, persistent inhibition of polymerization of hemoglobin S. We describe our first patient treated with lentiviral vector–mediated addition of an antisickling β-globin gene into autologous hematopoietic stem cells. Adverse events were consistent with busulfan conditioning. Fifteen months after treatment, the level of therapeutic antisickling β-globin remained high (approximately 50% of β-like–globin chains) without recurrence of sickle crises and with correction of the biologic hallmarks of the disease. (Funded by Bluebird Bio and others; HGB-205 ClinicalTrials.gov number, NCT02151526.)
Supported by Bluebird Bio and by a grant to the Biotherapy Clinical Investigation Center from Assistance Publique–Hôpitaux de Paris and INSERM.
Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.
Drs. Ribeil and Hacein-Bey-Abina and Drs. Leboulch and Cavazzana contributed equally to this article
We thank the staff at Necker Children’s Hospital for their important contributions to the care of the patient described in this article; our colleagues Zoubida Karim, Ph.D., of Université Paris Diderot, Laurent Kiger, Ph.D., and Marie Georgine Rakotoson, Ph.D., of Institut Mondor de Recherche Biomédicale, and Michel Bahuau of Centre Hospitalier Universitaire Henri Mondor for their contributions to the study; Laurent Kiger for creating and analyzing the oxygen-binding curves; Marie Georgine Rakotoson for creating and analyzing the density curves; Michel Bahuau for assessing the patient’s enzyme levels; Frédéric Galacteros for providing data on normal enzyme levels in patients with sickle cell disease; Mohammed Asmal, M.D., Ph.D., David Davidson, M.D., Tara O’Meara, Lilian Yengi, Ph.D., and Philip Gregory, Ph.D., of Bluebird Bio for their contributions to the study design and execution and for their critical review of an earlier version of the manuscript; and Katherine Lewis, an employee of Bluebird Bio, for editorial support in preparation of an earlier version of the manuscript.
SOURCE INFORMATION
From the Departments of Biotherapy (J.-A.R., A.M., E.M., L.C., M.C.), Clinical Pharmacy (P. Bourget), Pediatric Neuroradiology (D.G.), General Pediatrics (M.M.), and Pediatric Immunology–Hematology Unit (B.N., S.B.), Necker Children’s Hospital, Assistance Publique–Hôpitaux de Paris (AP-HP), Biotherapy Clinical Investigation Center, Groupe Hospitalier Universitaire Ouest, AP-HP, INSERM (J.-A.R., A.M., E.M., L.C., L.W., M.C.), Unité de Technologies Chimiques et Biologiques pour la Santé, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8258, INSERM Unité 1022, Faculté de Pharmacie de Paris, Université Paris Descartes, Chimie ParisTech (S.H.-B.-A.), Immunology Laboratory, Groupe Hospitalier Universitaire Paris-Sud, Hôpital Kremlin-Bicêtre, AP-HP, Le Kremlin-Bicêtre (S.H.-B.-A.), the Institute of Emerging Diseases and Innovative Therapies, Imagine Institute, Université Paris Descartes, Sorbonne Paris Cité University (M.S., B.N., L.W., M.C.), Mère-Enfant Clinical Investigation Center, Groupe Hospitalier Necker Cochin (M.S.), Université Paris Diderot, Sorbonne Paris Cité University, INSERM Institut National de Transfusion Sanguine, Unité Biologie Intégrée du Globule Rouge, Laboratoire d’Excellence GR-Ex (W.E.N.), and Laboratoires de Virologie, Hôpital Cochin (J.-F.M.), Paris, Atomic and Alternative Energy Commission, Université Paris-Sud, Fontenay-aux-Roses (E.P., Y.B., S.C., P.L.), Institut Mondor de Recherche Biomédicale, Equipe 2, Centre de Référence des Syndromes Drépanocytaires Majeurs, Centre Hospitalier Universitaire Henri Mondor, AP-HP, Laboratoire d’Excellence GR-Ex, Créteil (P. Bartolucci), and Université Paris Diderot, Sorbonne Paris Cité University, INSERM Unité 1149, Hôpital Louis-Mourier, AP-HP, Laboratoire d’Excellence GR-Ex, Colombes (H.P., T.L.) — all in France; Bluebird Bio, Cambridge (R.W.R., O.N., G.V., L.S., S.S.), and Brigham and Women’s Hospital and Harvard Medical School, Boston (P.L.) — both in Massachusetts; and Ramathibodi Hospital, Mahidol University, Bangkok, Thailand (P.L.).
Address reprint requests to Dr. Cavazzana at the Biotherapy Department, Necker Children’s Hospital, Assistance Publique–Hôpitaux de Paris, 149 rue de Sèvres, 75015 Paris, France, or at m.cavazzana@aphp.fr; or to Dr. Leboulch at the Institute of Emerging Diseases and Innovative Therapies, 18, rte du Panorama BP-6, 92265 Fontenay-aux-Roses, France, or at pleboulch@rics.bwh.harvard.edu.
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MEDIA IN THIS ARTICLE
FIGURE 1
Engraftment with Transduced Cells and Therapeutic Gene Expression in the Patient.
FIGURE 2
Results of Sickle Cell Disease–Specific Red-Cell Assays.
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BBC News: US ‘may split families that cross border’


I saw this on the BBC and thought you should see it:

US ‘may split families that cross border’ – http://www.bbc.co.uk/news/world-us-canada-39188033

BBC News: Trump signs new travel ban directive


I saw this on the BBC and thought you should see it:

Trump signs new travel ban directive – http://www.bbc.co.uk/news/world-us-canada-39183153

Watch “Gotham – 1×04 Music – Lacuna Coil – Spellbound” on YouTube


Track art

Spellbound

Lacuna Coil


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Lyrics

Burning here, in the room
Feeling that the walls are moving closer
Silent scene the dark takes me
Leads me to the ending of another day
I’m haunted

Tell me who you are. I am spellbound
You cannot have this control on me
Everywhere I go I am spellbound
I will break the spell you put on me

Velvet drapes, glowing candles
Silent whispers of words inside of my head
The night that comes, it waits for me
Lift me to the ending of another day
I’m haunted

Tell me who you are. I am spellbound
You cannot have this control on me
Everywhere I go I am spellbound
I will break the spell you put on me

Tell me who you are. I am spellbound
You cannot have this control on me
Everywhere I go I am spellbound
I will break the spell you put on me

Everywhere I go I am spellbound
Everywhere I go I am spellbound
Everywhere I go I am spellbound
I will break the spell you put on me

Written by Marco Biazzi, Marco Coti Zelati, Andrea Gaetano Ferro, Christiano Migliore, Cristiano Mozzati, Cristina Scabbia, Don Gilmore • Copyright © Kobalt Music Publishing Ltd., Universal Music Publishing Group

Image

Cetatea Făgăraș, la ceas de searăFoto: Camelia Bica


Image

Michelangelo BuonarrotiFemale head


“Cena in Emmaus”, miniatura tratta dal ‘Libro d’Ore di Carlo di Valois’ (1475-1500)


“Cena in Emmaus”, miniatura tratta dal ‘Libro d’Ore di Carlo di Valois’ (1475-1500)

“Cena in Emmaus”, miniatura tratta dal ‘Libro d’Ore di Carlo di Valois’ (1475-1500), Bibliothèque nationale de France, Parigi (fonte http://www.foliamagazine.it )