Tag Archives: Celgene

this day in the yesteryear: Insulin First Used to Treat Diabetes (1922)


Insulin First Used to Treat Diabetes (1922)

Insulin, a hormone produced in clusters of pancreatic cells called islets of Langerhans, regulates carbohydrate metabolism and allows the body to use and store glucose. Patients with diabetes have a decreased ability to either produce or absorb insulin. Canadian physiologists Charles Best and Sir Frederick Banting revolutionized the treatment of diabetes when they discovered how to isolate insulin in 1921. What happened when a 14-year-old diabetic was given the first insulin injection in 1922? More… Discuss

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Pomalidomide for Multiple Myeloma – National Cancer Institute


Pomalidomide for Multiple Myeloma – National Cancer Institute.

 

Otto Kahler

Otto Kahler (Photo credit: Wikipedia)

 

 

 

Multiple myeloma
Classification and external resources
Plasmacytoma ultramini1.jpg

Micrograph of a plasmacytoma, the histologiccorrelate of multiple myeloma. H&E stain
ICD10 C90.0
ICD9 203.0
ICD-O: M9732/3
OMIM 254500
DiseasesDB 8628
MedlinePlus 000583
eMedicine med/1521
MeSH D009101

 

Pomalidomide
Pomalidomide2DACS.svg
Systematic (IUPAC) name
4-Amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
Clinical data
Trade names Imnovid, Pomalyst
Licence data EMA:LinkUS FDA:link
Pregnancy cat. (US)
Legal status POM (UK) -only (US)
Routes Oral
Pharmacokinetic data
Protein binding 12–44%
Metabolism Hepatic (mostly CYP1A2 andCYP3A4 mediated; some minor contributions by CYP2C19 andCYP2D6)
Half-life 7.5 hours
Excretion Urine (73%), faeces (15%)
Identifiers
CAS number 19171-19-8 Yes
ATC code L04AX06
PubChem CID 134780
ChemSpider 118785 
UNII D2UX06XLB5 
ChEMBL CHEMBL43452 
Chemical data
Formula C13H11N3O4 
Mol. mass 273.24 g/mol

 

 

 

 

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