Tag Archives: Ebolavirus

EBOLA – The Plague Fighters – NOVA Documentary (invite your friends to learn about Ebola!)


EBOLA – The Plague Fighters – NOVA Documentary – FULL

The Ebola virus The Search for a Cure |BBC Full Documentary 2014 (ignorance, fear, unfounded hope: fight back with knowledge!)


The Ebola virus The Search for a Cure BBC Full Documentary 2014

this press for “unlikely” situations: Ebolavirus VP35 is a multifunctional virulence factor


English: Biosafety level 4 hazmat suit: resear...

English: Biosafety level 4 hazmat suit: researcher is working with the Ebola virus (Photo credit: Wikipedia)

Nurse-nun visits graves of victims of 1976 Zai...

Nurse-nun visits graves of victims of 1976 Zaire Ebola outbreak (Photo credit: Wikipedia)

English: Ebola virus virion. Created by CDC mi...

English: Ebola virus virion. Created by CDC microbiologist Cynthia Goldsmith, this colorized transmission electron micrograph (TEM) revealed some of the ultrastructural morphology displayed by an Ebola virus virion. (Photo credit: Wikipedia)

English: Color-enhanced electron micrograph of...

English: Color-enhanced electron micrograph of Ebola virus particles. Polski: Mikrofotografia elektronowa cząsteczek wirusa Ebola w fałszywych kolorach. (Photo credit: Wikipedia)

The isolation ward of Gulu Municipal Hospital,...

The isolation ward of Gulu Municipal Hospital, Gulu, Uganda, during an outbreak of Ebola hemorrhagic fever in October 2000 (Photo credit: Wikipedia)

Abstract

Ebola virus (EBOV) is a member of the filoviridae family that causes severe hemorrhagic fever during sporadic outbreaks, and no approved treatments are currently available. The multifunctional EBOV VP35 protein facilitates immune evasion by antagonizing antiviral signaling pathways and is important for viral RNA synthesis. In order to elucidate regulatory mechanisms and to develop countermeasures, we recently solved the structures of the Zaire and Reston EBOV VP35 interferon inhibitory domain (IID) in the free form and of the Zaire EBOV VP35 IID bound to dsRNA. Together with biochemical, cell biological and virological studies, our structural work revealed that distinct regions within EBOV VP35 IID contribute to virulence through host immune evasion and viral RNA synthesis. Here we summarize our recent structural and functional studies and discuss the potential of multifunctional Ebola VP35 as a therapeutic target.

Key words: filoviruses, ebola virus, marburg virus, VP35, IFN antagonist, RNA binding protein, virulence factor, immune evasion, drug target

via Ebolavirus VP35 is a multifunctional virulence factor.

this pressed: WHO Ebola situation assessment / What we know about transmission of the Ebola virus among humans


GENEVA, Switzerland, October 6, 2014/African Press Organization (APO)/ — Ebola situation assessment – 6 October 2014

The Ebola virus is transmitted among humans through close and direct physical contact with infected bodily fluids, the most infectious being blood, faeces and vomit.

The Ebola virus has also been detected in breast milk, urine and semen. In a convalescent male, the virus can persist in semen for at least 70 days; one study suggests persistence for more than 90 days.

Saliva and tears may also carry some risk. However, the studies implicating these additional bodily fluids were extremely limited in sample size and the science is inconclusive. In studies of saliva, the virus was found most frequently in patients at a severe stage of illness. The whole live virus has never been isolated from sweat.

The Ebola virus can also be transmitted indirectly, by contact with previously contaminated surfaces and objects. The risk of transmission from these surfaces is low and can be reduced even further by appropriate cleaning and disinfection procedures.

Not an airborne virus

Ebola virus disease is not an airborne infection. Airborne spread among humans implies inhalation of an infectious dose of virus from a suspended cloud of small dried droplets.

via WHO Ebola situation assessment / What we know about transmission of the Ebola virus among humans.

this pressed: WHO, CDC dissect Ebola transmission risk | CIDRAP ( Center for Infectious Disease Research and Policy)


Levent Konuk / iStock
A study in a patient-care setting found little Ebola virus persistence in non-bloody samples.

In the wake of suggestions from some experts that the Ebola virus could evolve into an airborne pathogen, the World Health Organization (WHO) took pains to explain today that the virus is known to spread only through contact with bodily fluids—mainly blood, feces, and vomit.

The agency also said that the virus has been detected in breast milk, urine, and semen, and that even saliva and tears may pose some risk.

Meanwhile, the US Centers for Disease Control and Prevention (CDC), in updated guidance for infection control in hospitals, said the virus can persist on environmental surfaces for a few days. But with daily cleaning and disinfection in a US hospital environment, it would be unlikely to survive longer than a day, the agency said.

via WHO, CDC dissect Ebola transmission risk | CIDRAP.