Tag Archives: Lausanne

An important step forward for better metabolic health


 

Lausanne, Switzerland, July 17, 2014 – New research led by scientists at the Nestlé Institute of Health Sciences (NIHS) could provide a clue to combat the growing epidemic of metabolic disorders. This work makes an important contribution to the knowledge and expertise that NIHS can apply in the future to develop nutritional solutions for improving metabolic health.

AMP-activated protein kinase (AMPK) is an enzyme that acts as a central molecular switch whose activation has many beneficial effects on metabolism. AMPK can be naturally activated by exercise in muscle, but if we also knew how to activate AMPK, for example, by diet, we could better control energy balance and maintain metabolic health. Regulation of AMPK is complex: it is controlled by the interplay between 3 subunits (a catalytic α subunit and regulatory β and γ subunits) and each subunit has multiple isoforms. A handful of synthetic small molecules have been reported to directly stimulate AMPK but, apart from thienopyridones (which stimulates AMPK through binding to one of the β subunit isoforms), precisely how they work has not yet been described.

Through a highly successful collaborative effort by an international team of scientists led by Prof. Kei Sakamoto and his group at NIHS, a research project was undertaken to characterise a recently identified AMPK activator. They identified a unique mechanism of action that displays a preference for a particular AMPK α-complex isoform.

via  An  important step forward for better metabolic health.

****Access Nestle Metabolic chart (PDF) here

 

 

 

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this day in the yeasteryear: The International Olympic Committee Is Founded (1894) (THIS POST IS NOT EXPLOITED BY coca-cola)


The International Olympic Committee Is Founded (1894)

Based in Lausanne, Switzerland, the International Olympic Committee (IOC) was founded following efforts by Pierre de Coubertin to reinstate the ancient Olympic Games that were first held in Greece in 776 BCE. Today, the IOC constitutes a single legal entity that organizes the Summer and Winter Olympic Games and owns copyrights, trademarks, and other intangible properties associated with the Games, such as the Olympic logos. What is the maximum number of members the IOC can have? More… Discuss