The use of over-the-counter painkillers may lower one’s risk of squamous cell skin cancer—typically caused by sun exposure—by 15 percent, according to a new study. Researchers suspect that Ibuprofen and naproxen—the active ingredients found in the popular drugs Advil, Motrin, and Aleve—disrupt the proteins in the body that contribute to cancerous tumors. The scientists caution that more research is necessary, since painkillers carry their own risks. More… Discuss
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Tagged American Cancer Society, Analgesic, Brisbane, Cancer, Ibuprofen, Journal of Investigative Dermatology, Multiple myeloma, Naprosyn coupon, Non-steroidal anti-inflammatory drug, Skin cancer, Squamous-cell carcinoma
Treatment inhibits key process that enables cancer cells to multiply.
Researchers in London plan to begin clinical trials on a significant new treatment for multiple myeloma by the end of next year.
In laboratory testing, the drug, known as DTP3, killed myeloma cells within human cells and mice without causing any toxic side effects. In a paper published on October 13, 2014 in Cancer Cells, researchers outlined how the drug inhibits a key process that allows cancer cells to multiply.
“Lab studies suggest that DTP3 could have therapeutic benefit for patients with multiple myeloma and potentially several other types of cancer, but we will need to confirm this in our clinical trials, the first of which will start next year,” said lead researcher Professor Guido Franzoso in a press release.
DTP3 was developed through an evaluation of the mechanisms that enable cancer cells to continue multiplying beyond their normal lifespan. Specifically, the researchers studied a protein called nuclear factor kappa B (NF-kB), which plays a key role in inflammation, in addition to immune and stress response systems.
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Tagged Cancer, Cancer cell, Cell biology, Clinical trial, DTP3, Franzoso, London, Multiple myeloma, NF-κB
When stressed cells go into survival mode and try repairing themselves, bad things can happen. One impact is a biological pathway that can support cancer and promote its progression.
This is a story about one such pathway in multiple myeloma, the most devastating tumor-bone disease.
The associate professor of dental medicine, with a doctoral degree in oral health sciences at the University of Pittsburgh School of Dental Medicine, is an endodontist, or root-canal specialist. Her research is what excited the NIH.
“We’ve identified a novel pathway and the role of that pathway in modulating the bone-marrow environment on a microenvironment level in support of multiple myeloma,” Ms. Ouyang said…
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Tagged American Cancer Society, Dana–Farber Cancer Institute, David Templeton, Multiple myeloma, National Institutes of Health, Pittsburgh, Pittsburgh Post-Gazette, University of Pittsburgh School of Dental Medicine
Giving Viruses a License to Kill…Cancer The lab of Dr. Mark Federspiel at the Mayo Clinic, where the measles virus is being grown in bioreactors for the next clinical trial coming up in September. Photo by Mayo Clinic
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Tagged Cancer, Clinical trial, mayo clinic, Measles, Multiple myeloma, September, Stephen Russell, virus
Researchers are cautiously optimistic about an experimental cancer treatment that uses a modified measles virus to target and kill cancerous cells. Two out of six multiple myeloma patients who were treated with extremely high doses of the engineered viruses responded to the treatment, with one appearing to enter into complete remission. These two patients were found to have few or no circulating measles antibodies, important because this affords the virus a chance to attack the cancer cells before the patient’s immune system begins fighting off the virus. More… Discuss
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Tagged Cancer, cancer cells, Clinical trial, Cure, experimental cancer treatment, mayo clinic, Measles, Measles vaccine, Measles Virus, Multiple myeloma, multiple myeloma patients, Patient, virus
Otto Kahler (Photo credit: Wikipedia)
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Tagged Cancer, Celgene, Conditions and Diseases, European Commission, Health, Multiple myeloma, National Cancer Institute, Pomalidomide