Tag Archives: Zaire

this day in the yesteryear: The Rumble in the Jungle (1974)


The Rumble in the Jungle (1974)

The “Rumble in the Jungle” pitted boxer Muhammad Ali against heavyweight champion George Foreman in Zaire—now the Democratic Republic of the Congo. The match is remembered for Ali’s incredible performance in regaining the heavyweight title. Surrounded by spellbound fans, he used a strategy later dubbed the “rope-a-dope” to tire Foreman before winning in the eighth round. This fight was Don King‘s first major venture as a professional boxing promoter. What musical acts were booked for the event? More… Discuss

EBOLA – The Plague Fighters – NOVA Documentary (invite your friends to learn about Ebola!)


EBOLA – The Plague Fighters – NOVA Documentary – FULL

this press for “unlikely” situations: Ebolavirus VP35 is a multifunctional virulence factor


English: Biosafety level 4 hazmat suit: resear...

English: Biosafety level 4 hazmat suit: researcher is working with the Ebola virus (Photo credit: Wikipedia)

Nurse-nun visits graves of victims of 1976 Zai...

Nurse-nun visits graves of victims of 1976 Zaire Ebola outbreak (Photo credit: Wikipedia)

English: Ebola virus virion. Created by CDC mi...

English: Ebola virus virion. Created by CDC microbiologist Cynthia Goldsmith, this colorized transmission electron micrograph (TEM) revealed some of the ultrastructural morphology displayed by an Ebola virus virion. (Photo credit: Wikipedia)

English: Color-enhanced electron micrograph of...

English: Color-enhanced electron micrograph of Ebola virus particles. Polski: Mikrofotografia elektronowa cząsteczek wirusa Ebola w fałszywych kolorach. (Photo credit: Wikipedia)

The isolation ward of Gulu Municipal Hospital,...

The isolation ward of Gulu Municipal Hospital, Gulu, Uganda, during an outbreak of Ebola hemorrhagic fever in October 2000 (Photo credit: Wikipedia)

Abstract

Ebola virus (EBOV) is a member of the filoviridae family that causes severe hemorrhagic fever during sporadic outbreaks, and no approved treatments are currently available. The multifunctional EBOV VP35 protein facilitates immune evasion by antagonizing antiviral signaling pathways and is important for viral RNA synthesis. In order to elucidate regulatory mechanisms and to develop countermeasures, we recently solved the structures of the Zaire and Reston EBOV VP35 interferon inhibitory domain (IID) in the free form and of the Zaire EBOV VP35 IID bound to dsRNA. Together with biochemical, cell biological and virological studies, our structural work revealed that distinct regions within EBOV VP35 IID contribute to virulence through host immune evasion and viral RNA synthesis. Here we summarize our recent structural and functional studies and discuss the potential of multifunctional Ebola VP35 as a therapeutic target.

Key words: filoviruses, ebola virus, marburg virus, VP35, IFN antagonist, RNA binding protein, virulence factor, immune evasion, drug target

via Ebolavirus VP35 is a multifunctional virulence factor.

Democratic Republic of Congo Independence Day


Democratic Republic of Congo Independence Day

The Democratic Republic of the Congo (formerly Zaire) gained independence from Belgium on this day in 1960. It had been a Belgian colony since 1907, and powerful movements had struggled for self-rule since the 1950s. The people celebrated the first independence day with fireworks and bonfires in the capital city of Léopoldville (now Kinshasa). More… Discuss